TIME TRENDS IN THE INCIDENCE OF BILIARY ATRESIA

肝外胆道闭锁是一种早期表现的肝病。 婴儿期，表现为肝外胆汁逐渐闭塞 风管。据估计，这一比例从每8000人中就有一人发生到每8000人中就有一人 15000活产，是表现最常见的单一指标 在儿童肝移植中的应用。所有的发病率数字都不是 基于明确定义的地缘政治区域；对 这种情况的频率是从转诊中心得出的。一些人 研究人员提出了这种情况的时空聚集性。 该项目将收集所有案件的信息在一个明确的 地缘政治领域大约10年，出生证明将 将被获得。病例将与该地区的其他新生儿进行比较，以确定 发病率和聚集性变化的证据。预计将会有一个 选址工作将于1986年开始。

Extrahepatic biliary atresia is a liver disease presenting in early infancy, manifested by progressive obliteration of the extrahepatic bile ducts. It has been estimated to occur in from one per 8000 to one per 15000 live births, and is the single most common indication for performance of liver transplantation in children. None of the incidence figures is based on a well defined geopolitical region; most estimates of the frequency of this condition are derived from referral centers. Some investigators have suggested a time-space clustering of this condition. This project will gather information on all cases in a well defined geopolitical area for approximately 10 years, and birth certificates will be obtained. Cases will be compared to the other births in the area for evidence of changes in incidence and clustering. It is anticipated that a site will be selected and field work begin in 1986.