The Avon Longitudinal Study of Parents and Children (ALSPAC): A multi-generation, longitudinal resource

“从1991年4月到1992年12月，我们在ALSPAC登记了14000名孕妇，其中14062名活产。在多个时间点对此次招募的母亲、父亲、儿童以及现在的儿童进行了随访，并收集了各种样本、暴露和结果测量。我们的使命是确保ALSPAC仍然是首屈一指的多代出生队列，提供无与伦比的数据和样本访问。我们将照顾现有的样本和数据，提高现有资源的可见性和可访问性，最大限度地连接行政数据，并继续收集新的数据和样本。保持这种宝贵的英国资源将使研究具有独特的能力，可以跟踪整个生命周期中健康和幸福的变化，影响因素是什么，某些因素如何跨代起作用，以及社会变化如何影响相隔30年经历类似事件的家庭的健康和幸福。”

"Between April 1991 and December 1992 we enrolled >14000 pregnant women in ALSPAC resulting in 14062 live births. Mothers, fathers, children and now children of the children from this recruitment have been followed up at multiple timepoints and a wide variety of samples, exposure and outcome measures collected.Our mission is to ensure ALSPAC remains the premier multi-generational birth cohort offering unrivalled access to data and samples. We will look after the existing samples and data, improve visibility and access to the existing resource, maximise the connection of administrative data and continue collecting new data and samples.Maintaining such a valuable UK resource will enable research uniquely equipped to follow changes in health and well-being across the lifespan, what affects this, how certain factors work across generations, and how changes in society affect the health and well-being of families going through similar events 30 years apart."