Phase 1 COVID-19 Data and Connectivity – National Core Study (Phase 1 D&C-NCS)

数据和连通性研究与其他国家核心研究交叉，提供国家卫生数据研究能力，以支持COVID-19研究问题，确保数据集可被发现和访问，并建立联系，以回答其他五个国家核心研究的优先研究问题。为更广泛的研究提供数据将增加超出上述特定研究的利益范围，导致意想不到的利益，并更普遍地提高英国的研究能力，增加NCS项目的投资回报。数据整合以及方法和标准的统一将有助于快速研究和开发跨2019冠状病毒病的新干预措施和技术，并将知识和技术转移到其他临床和公共卫生领域。数据集之间的整理和联系对于将核心研究整合在一起至关重要，确保每个研究都能根据其政策优先事项提供服务，例如，医院数据目前可能无法与全科医生数据和更广泛的社区数据（例如社会经济数据或住房和建筑环境数据）联系起来。需要对这些数据集进行访问、清理、链接和使用，以充分了解这些因素和结果之间的联系。2019冠状病毒病数据和连通性研究的交付将涉及与数据保管人、公众和患者以及全英国国家可信研究环境（TREs）的提供者的密切互动，以确保所需数据的安全可靠存储，随时可供批准的研究人员使用，并与计算、分析和数据服务相关联，从而更容易以透明和可信的方式解决优先研究问题。第一阶段将：•继续应对新出现的COVID-19研究优先事项，绘制国家核心研究、NIHR UPH研究和SAGE子小组所需的关键数据集，以允许研究可以为整个英国的政策和运营决策提供信息•进一步开发全英国的数据基础设施和服务，以便更快地访问高优先级的卫生、行政、分子、以及为从事最重要的covid - 19相关研究的研究人员提供行为数据资产，确保能够以透明和值得信赖的方式有效回答优先研究问题。•通过包容性四国方法加强和扩展现有的国家可信研究环境（TRE）和英国健康数据研究创新门户基础设施，确保COVID-19研究的优先数据集作为一个单一的商店窗口可查找、可访问、可互操作和可重复使用（FAIR）

The Data and Connectivity study sits across the other National Core Studies and delivers a national health data research capability to support COVID-19 research questions, ensuring datasets are discoverable and accessible and linkages are established to answer the priority research questions from the other five National Core Studies. Making data available for wider research use will increase the scope of benefits beyond the specific studies above, leading to unexpected benefits and boosting UK research capacity more generally, increasing return on investment for the NCS programme. Data integration and harmonisation of methods and standards will enable rapid research and development of new interventions and technologies across the spectrum of COVID-19, and knowledge and technology transfer to other clinical and public health areas. Collation and linkage between datasets is critical to bringing the core studies together, ensuring that each of them can deliver against their policy priorities e.g. hospital data may not currently be linked with GP data and wider community data (e.g. socioeconomic data or data on housing and the built environment). Access, cleaning, linkage and use of these datasets together is needed to fully understand links between these factors and outcomes.Delivery of the COVID-19 Data and Connectivity Study will involve close interaction with data custodians, the public and patients, and providers of UK-wide national Trusted Research Environments (TREs) to ensure the required data is stored safely and securely, made readily available to approved researchers and is associated with compute, analytical and data services that make it easier to address priority research questions in a transparent and trustworthy way.Phase 1 will:• Continue to respond to emerging COVID-19 research priorities, mapping key datasets required by the National Core Studies, NIHR UPH Studies and SAGE sub-groups to allow research which can inform policy and operational decision making across the UK• Further develop the data infrastructure and services across the UK to allow faster access to high priority health, administrative, molecular, and behavioural data assets for researchers working on the most important COVID-related studies, ensuring priority research questions can be answered efficiently, in a transparent and trustworthy way. • Strengthen and extend the existing national Trusted Research Environments (TRE) and UK Health Data Research Innovation Gateway infrastructure through inclusive four nations approach ensuring the priority datasets for COVID-19 research are findable, accessible, inter-operable and reusable (FAIR) as a single shop window