THE ROLE OF SUBCLINICAL INFECTION AND CYTOKINES IN PRETERM PARTURITION

实验室完成了以下研究： 1. 脐带血白细胞介素-6浓度测定 有发生白色病变风险的婴儿 脑室周围白质软化（PVL）：PVL是一种常见的白色物质 早产儿中枢神经系统损害和一个主要风险 脑瘫的危害有哪些 一系列研究旨在 测试是否由马槟榔碱介导的神经损伤的假设 对这种情况负责。 分支的调查人员发现， 脐带中的IL-6测定可以识别婴儿患 PVL相关病变。 2. 三分之二的自然流产/胎儿死亡是遗传性的， 妊娠中期子宫内膜穿刺术是预先存在的亚临床 羊膜腔的炎症过程： 妊娠中期子宫内膜穿刺术发生在0.05%的病例中， 被归因于程序。 白细胞介素-6（IL-6）是一种细胞因子 通常存在于人类羊水中，并且其浓度增加 在感染过程中。 该分支规定， 接受中期子宫内膜穿刺术，那些随后有 自然流产/胎儿死亡的羊水量较高 IL-6浓度高于足月正常分娩者。这 表明预先存在的炎症过程是一个重要的风险， 流产的因素，羊水IL-6浓度可以 识别有风险的患者。 3. 前列腺素：劳动的原因或后果？： 前列腺素具有 被认为是所有分娩开始的关键介质 哺乳动物物种。 最近，关于是否 兰丁参与分娩或被释放， 劳动的结果。 这场辩论的一个关键问题是， 白藜芦醇生物合成的增加发生在 劳动 这个问题从未在人类身上得到解决。 因此，委员会认为， 分支进行了一项研究，以确定羊水是否 前列腺素浓度增加之前，劳动力的发病， 人类 这项研究表明，羊水中的 PGE和PGF的液体浓度发生在发病之前， 自然分娩和羊水的额外增加 PGE和PGF浓度在临产早期就已存在。 这些数据支持 在人类分娩的开始中的作用。

The laboratory concluded the following studies: 1. Interleukin-6 concentrations in umbilical cord plasma identify infants at risk for the development of white matter lesions associated with periventricular leukomalacia (PVL): PVL is a common white matter lesion of the central nervous system of preterm neonates and a major risk factor for cerebral palsy. A series of studies have been designed to test the hypothesis of whether cytokine-mediated neural injury is responsible for this condition. Investigators of the Branch found that IL-6 determinations in umbilical cord can identify infants at risk for PVL-associated lesions. 2. Two thirds of spontaneous abortion/fetal deaths after genetic midtrimester amniocentesis are the result of a pre-existing subclinical inflammatory process of the amniotic cavity: Pregnancy loss after midtrimester amniocentesis occurs in 0.05% of cases and generally has been attributed to the procedure. Interleukin-6 (IL-6) is a cytokine normally present in human amniotic fluid and its concentration increases in the course of infection. The Branch established that of among women undergoing midtrimester amniocentesis, those who subsequently had a spontaneous abortion/fetal demise had a higher amniotic fluid concentration of IL-6 than those who had a normal delivery at term. This suggests that pre-existing inflammatory process is an important risk factor for pregnancy loss and that amniotic fluid IL-6 concentration can identify patients at risk. 3. Prostaglandins: Cause or consequence of labor?: Prostaglandins have been considered the key mediators for the onset of labor for all mammalian species. Recently, intense debate has developed as to whether prostaglandins participate in the initiation of labor or are released as a consequence of labor. A crucial issue in this debate is whether an increase in prostaglandins biosynthesis occurs prior to the onset of labor. This question has never been addressed in humans. Consequently, the Branch conducted a study to determine whether amniotic fluid prostaglandin concentrations increase prior to the onset of labor in humans. This study established that a significant increase in amniotic fluid concentrations of PGE and PGF occurred prior to the onset of spontaneous labor and that an additional increase in amniotic fluid concentrations PGE and PGF was found in early labor. These data support a role for prostaglandins in the initiation of human parturition.