Determining how the germ layer of origin of adult somatic cells influences the differentiation potential of iPS cells.

诱导多能干细胞（iPS）来源于成熟细胞，能够分化为任何成体细胞类型。我们先前表明，iPS细胞来源的细胞影响其分子特性。在这里，我们建议调查成人细胞的共同胚胎起源如何影响iPS细胞的分化潜能。我们的研究结果可能表明，在衍生iPS细胞用于细胞替代疗法时，应使用哪种成熟细胞类型。

Induced pluripotent stem cells (iPS) are derived from mature cells and are capable to differentiate into any adult cell types. We previously showed that the cells from which iPS cells are derived affect their molecular properties. Here we propose to investigate how the common embryonic origin of adult cells affects the differentiation potential of iPS cells. Our results may indicate which mature cell types should be used when deriving iPS cells for use in cellular replacement therapies.