Determining the influences of cell stress and heat shock factor-1 action in osteoclast formation and pathological bone loss.

癌症和类风湿性关节炎会导致疼痛的骨破坏。这是由于称为破骨细胞的骨破坏细胞数量增加而发生的。我们发现骨细胞的应激反应可以通过激活骨细胞内的蛋白质来增加破骨细胞的数量，从而促进破骨细胞的形成。因此，我们将研究细胞应激阻断药物是否可以阻止骨质流失。由于关节炎和癌症都会引起应激反应，这项工作可以确定这类疾病影响骨骼的新方式。

Cancer and rheumatoid arthritis cause painful bone destruction. This occurs due to increased numbers of bone destroying cells called osteoclasts. We found stress responses in bone cells can increase osteoclast numbers by activating proteins inside the bone cells that encourage osteoclasts to form. We will thus study whether cell stress blocking drugs might stop bone loss. As arthritis and cancer both cause stress responses, this work could identify a new way that such diseases affect bone.