BEHAVIORAL & PHYSIOLOGICAL CONCOMITANTS OF DRUG ABUSE

SPID编号：1 该项目的目的是描述可卡因的影响， 相关兴奋剂对非人类中枢神经系统和行为的影响 灵长类动物 药物对习得性、条件性操作行为的影响是一种 主要焦点。 使用的方法包括改变时间表控制 行为作为中枢神经系统活动的指标，静脉注射 自我给药，以表明增强疗效，或 滥用倾向和药物作为歧视性刺激控制 行为通过使用单胺激动剂和拮抗剂， 实验室已经证明了特定的神经递质的参与 系统的行为，加强和歧视的影响， 可卡因和其他与高滥用倾向有关的选定药物。 上一个日历年的进展进一步澄清了 介导可卡因作用的多巴胺能系统 行为 此外，还开发了体内微透析技术 用于有意识的猴子，以允许测量直接 与药物对行为的影响有关的神经化学变化。 细胞外多巴胺的显著增加被证明是在 可卡因管理。 随后的实验将研究 可卡因能化合物阻断可卡因诱导的神经化学物质 变化 长期目标是描述行为和 可卡因的神经化学作用，并确定其他药物， 在治疗兴奋剂滥用方面具有治疗价值。

SPID#: 1 The aim of this project is to characterize the effects of cocaine and related stimulants on the central nervous system and behavior in nonhuman primates. Drug effects on learned, conditioned operant behavior is a major focus. Methods used include changes in schedule-controlled behavior as an index of central nervous system activity, the intravenous self-administration of drugs as indicative of reinforcing efficacy or abuse liability, and drugs as discriminative stimuli controlling behavior. Through the use of monoamine agonists and antagonists, this laboratory has demonstrated the involvement of specific neurotransmitter systems in the behavioral, reinforcing and discriminative effects of cocaine and other selected drugs associated with high abuse liability. Progress during the previous calendar year further clarified the role of the serotonergic system in the mediation of cocaine's effects on behavior. In addition, in vivo microdialysis techniques were developed for use in conscious monkeys to allow for the measurement of direct neurochemical changes associated with drug effects on behavior. Pronounced increases in extracellular dopamine were demonstrated during cocaine administration. Subsequent experiments will investigate the ability of serotonergic compounds to block cocaine-induced neurochemical changes. The long-range objective is to characterize the behavioral and neurochemical effects of cocaine and to identify other drugs that may have therapeutic value in treating stimulant abuse.