Paediatric Brain Monitoring with Information Technology (KidsBrainIT): Using Information Technology (IT) Innovations to Improve Childhood brain trauma

项目目的：我们的目标是验证两个假设：在持续的创伤性脑损伤（TBI）后，测量脑灌注压（CPP）在计算的最佳CPP （CPPopt）范围内维持较长时间的儿科患者有：(1)改善的结果，(2)对颅内压（ICP）升高的耐受性更好。工作计划：我们建立了一个新的多中心、多学科、多国家的临床和研究合作项目——KidsBrainIT。在一项为期2年的前瞻性观察研究中，10个中心将儿科TBI患者的恼人临床、高分辨率生理和结果数据提供给一个中央存储库（KidsBrainIT数据库）。使用与我们的试验相同的方法（最佳CPP计算和ICP剂量响应图），主要数据集用于检验我们的假设。用于测试新技术和数据模型的数据子集。计算验证的指标被用作临床管理质量保证的指标，反馈给贡献单位以改善治疗。利用成果：KidsBrainIT将来自不同中心和国家的资深临床医生、工程师和科学家带到小组中，促进了临床相关治疗阈值的测试，并验证了新的监测技术，这些技术随后很容易通过贡献单位转化为临床实践。它还将解决成人和儿科做法之间的不平等和管理差异。

PROJECT AIM: We aim to test two hypotheses: After sustaining traumatic brain injury (TBI), paediatricpatients with a longer period of measured cerebral perfusion pressure (CPP) maintained within thecalculated optimal CPP (CPPopt) ranges have (1) an improved outcome, and (2) better toleranceagainst raised intracranial pressure (ICP).WORK PLAN: We set up a new multi-centre, multi-disciplinary and multi-national clinical and researchcollaborative called KidsBrainIT. In a 2-year prospective observational study, 10 centres contributepaediatric TBI patients' annoymised clinical, high-resolution physiological, and outcome data to a centralrepository (KidsBrainIT Data-bank). Using the same methodology as our pilot (optimal CPP calculationand ICP dose-response plots), the main data-set is used to test our hypotheses. A sub-set of data isused to test novel technology and data models. Calculated validated indices is used as metrics ofclinical management quality assurance for feedback to contributing units to improve treatment.EXPLOITATION OF RESULTS: By bringing senior clinicians, engineers, and scientists from differentcentres and countries to the group, KidsBrainIT facilitates testing of clinically relevant therapeuticthresholds and validating new monitoring technologies which are then readily translated back intoclinical practice through contributing units. It will also address inequality and variations in TBImanagement between adult and paediatric practices.