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Multimodal imaging and analysis for monitoring physiological changes during brain injury

用于监测脑损伤期间生理变化的多模态成像和分析

基本信息

批准号：
2749894
负责人：
金额：
--
依托单位：
University of Nottingham
依托单位国家：
英国
项目类别：
Studentship
财政年份：
2022
资助国家：
英国
起止时间：
2022 至无数据
项目状态：
未结题

来源：
https://gtr.ukri.org/projects?ref=studentship-2749894
关键词：
Multimodal imaging analysis monitoring physiological

项目摘要

Annually in the UK, there are 100,000 strokes and 160,000 people admitted to hospital with a traumatic head injury - it is estimated that over 2 million people live with the long-term, debilitating consequences of a stroke or head injury.Currently, we lack tools for effectively treating and monitoring brain injuries. One major limitation in developing new therapies is our lack of knowledge of the function and condition of brain tissue during and after traumatic and non-traumatic injury.This project will develop and apply molecular imaging and microRNA analyses to monitor the physiological and molecular biomarkers of brain tissue during and after brain injuries. Rodent models of both stroke and traumatic brain injury will be used to compare approaches and results across pathologies. Comparison and cross-validation of magnetic resonance imaging (MRI) and microRNA datasets will enhance the biological data obtained and increase likelihood of clinical translation.This highly interdisciplinary project will involve chemical synthesis, histology, in vivo experiments, and analysis of MRI and microRNA datasets. The supervisory team and experimental facilities spans multiple complimentary departments, including the Schools of Medicine, Chemistry, Psychology, Sir Peter Mansfield Imaging Centre, and Precision Imaging Beacon at UoN, and Institute of Inflammation and Ageing at UoB.

在英国，每年有100，000人中风，160，000人因创伤性头部损伤入院治疗-据估计，超过200万人长期生活在中风或头部损伤的衰弱后果中。目前，我们缺乏有效治疗和监测脑损伤的工具。本项目将开发和应用分子成像技术和microRNA分析技术，以监测脑损伤期间和之后脑组织的生理和分子生物标志物。中风和创伤性脑损伤的啮齿动物模型将用于比较不同病理的方法和结果。磁共振成像（MRI）和microRNA数据集的比较和交叉验证将增强所获得的生物数据，并增加临床翻译的可能性。这个高度跨学科的项目将涉及化学合成，组织学，体内实验以及MRI和microRNA数据集的分析。监督团队和实验设施跨越多个互补部门，包括华盛顿大学的医学院、化学学院、心理学学院、彼得·曼斯菲尔德爵士成像中心和精密成像信标，以及华盛顿大学的炎症和衰老研究所。