CORE--LABORATORY ANIMALS

衰老和阿尔茨海默氏症研究中心实验动物中心 作为一种共享资源，它促进，丰富和协调动物 中心五个组成项目中的四个的模型研究 提议 在以往的赠款和项目期间， 发展和维持屏障持续，无疾病的殖民地， 常规、老化、超老化和终身（超过39个月）热量 为了减少数据， 为新的和正在进行的研究牺牲动物变量。 我们有 从所有实验菌落中消除感染因子，构建 并翻修了新的有障碍的住房区， 行为模拟研究动物的饲养环境条件 行为测试实验室与动物饲养室相邻。 这一核心组成部分的一个具体目标是继续提供 专门维护屏障持续移植，常规， 热量限制、6-OHDA模型和对照老年大鼠。 芯会 继续促进动物模型研究的各个方面，如以前一样， 制定并实施。 第二个具体目标是提供其他核心 为老龄中心调查人员提供的服务，包括全面的毛额和 实验动物的组织病理学评价，血清学 监测以记录持续的病毒（特别是细小病毒）， 支原体无病状态及实验室持续会诊 老年大鼠的动物遗传学、建模和自发性疾病评估。 第三个具体目标是保持并向中心研究者提供 营养（热量）限制，年龄（大于30个月）的Fisher 344大鼠。 在第四个具体目标中，核心主任将开发一个新的、自动化的 数据库，将包括，监测和跟踪所有实验动物 用于所有项目。 所有项目动物将唯一标识为 植入了电子应答器芯片 该数据库将 与所有中心研究者联网并可访问。 芯会 协调项目内部和项目之间所有动物的使用， 最大限度地提高动物使用效率， 不必要和多余的动物使用。

The Aging and Alzheimer's Research Center Laboratory Animal Core operates as a shared resource which facilitates, enriches and coordinates animal model studies for four of the five component projects in the Center proposal. This Core has, over previous grant and project periods, developed and maintained barrier-sustained, disease-free colonies of conventional, aged, ultra-aged and lifetime (more 39 months) caloric restricted, neurologically modeled rats in order to reduce data compromising animal variables for new and ongoing studies. We have eliminated infectious agents from all experimental colonies, constructed and renovated new barriered housing areas, established improved environmental conditions for housing behavioral modeled research animals with behavioral testing laboratories contiguous to animal housing rooms. One specific aim of this core component is to continue to provide specialized maintenance of barrier sustained transplant, conventional, caloric-restricted, 6-OHDA modeled and control aged rats. The core will continue to facilitate all aspects of animal model studies as previously developed and implemented. A second specific aim is to provide other core services to Aging Center investigators including comprehensive gross and histopathological evaluations of experimental animals, serological surveillance to document a continuing virus (especially parvovirus) and mycoplasma disease-free status and continuous consultation on laboratory animal genetics, modeling and spontaneous disease evaluations in aged rats. A third specific aim is to maintain and provide Center investigators with nutritionally (caloric) restricted, aged (more 30 months) Fisher 344 rats. In the fourth specific aim, the Core Director will develop a nw, automated data base which will include, monitor and track all experimental animals used in all projects. All project animals will be uniquely identified with implanted with electronic, transponder microchips. This database will be networked to and be accessible by all Center investigators. The Core will coordinate the use of all animals within and between projects in order to maximize the efficiency of animal use and eliminate any potential unnecessary and redundant animal use.