NutriPROGRAM: Early-life Nutritional Programming of Metabolic Health through Epigenetic Pathways

孕期和婴儿期是代谢健康营养规划的关键时期。表观遗传变化似乎在整个生命过程中从早期营养到新陈代谢健康的途径中起着至关重要的作用。NutriProGram将研究与不同年龄的母亲和子女的DNA甲基化有关的关键母婴营养暴露，以及整个生命过程中的代谢健康。NutriProGram将特别侧重于因果关系、营养、生活方式、体力活动和微生物区系导致的DNA甲基化变化的可逆性、DNA甲基化变化的功能后果以及转化为预防或人口健康战略。最终，NutriProGram将发展一种可持续的、可转换的国际合作，研究营养和表观遗传学及其在整个生命过程中保持良好健康的作用。

Pregnancy and infancy are critical periods for nutritional programming of metabolic health. Epigenetic changes seem to have a crucial role in pathways leading from early-life nutrition to metabolic health across the life course. NutriPROGRAM will study key maternal and infant nutrition-related exposures in relation to DNA methylation in mothers and offspring at different ages, and metabolic health across the life course. NutriPROGRAM will specifically focus on cause-and-effect relationships, reversibility of DNA methylation changes by nutrition, lifestyle, physical activity and microbiota, functional consequences of DNA methylation changes and translation into preventive or population-health strategies. Eventually, NutriPROGRAM will develop a sustainable, translational, international collaboration for studies on nutrition and epigenetics and their role in sustaining good health throughout the life course.