CORE--DATA MANAGEMENT AND STATISTICS

1)核心单元的数据管理部分提供收集， 存储和检索来自中心所有单位的数据。 2)核心单位的统计科向所有人提供专门知识 研究者对研究进行分析和解释。 数据管理股提供广泛的计算机设施， 连接长老会医院和哥伦比亚主校区 电脑该单位每天从医院电脑下载所有 与患者和患者相关的临床和实验室数据 所有病人的病历的详细摘要。的重要目标 统计部分的核心单元是生成预后因子， 根据我们自己对数百名患者的数据， 遗传修饰剂和血液学数据与临床表现 疾病。证明相对较低的血红蛋白阈值 F浓度（大于或等于4%）赋予保护， 中风还表明，可能增加Hgb F浓度的药物可能 导致预防这种和其他镰刀的毁灭性并发症 细胞疾病。一个更复杂和全面的画面将被生成 提供详细的预后因素， 为特定的患者提供治疗方案。

1)The data management section of the core unit provides collection, storage and retrieval of data from all units of the center. 2) The statistical section of the core unit offers expertise to all investigators for analysis and interpretation of studies. The data management unit provides an extensive computer facility, with links to both the Presbyterian Hospital and the Columbia main campus computers. The unit downloads daily from the hospital computer all clinical and laboratory data relative to the patients and furnishes detailed summary to all patients' charts. An important goal of the statistical section of the core unit is to generate prognostic factors, from our own data on several hundred patients, by correlation of the genetic modifiers and hematological data with the clinical manifestations of the disease. The demonstration that a relatively low threshold of Hgb F concentration (greater than or equal to 4%) confers protection from stroke also suggests that drugs that may increase Hgb F concentration may result in prevention of this and other devastating complications of sickle cell diseases. A more complex and comprehensive picture will be generated to provide detailed prognostic factors that could be used to selectively program to specific patients that available therapies.