FUNCTIONAL ORGANIZATION OF THE BRAIN IN CHILDREN WITH ADHD--INTERVENTION EFFECTS

项目I将研究注意力的神经生物学基础-- 使用功能磁共振的缺陷/多动障碍(ADHD) 对最初的中心计划招募的儿童进行成像(FMRI)研究。 具体来说，最初评估为7.5-13.3岁的儿童将是 在11-16岁时系统地重新评估。样本和 我们的研究小组在使用功能磁共振成像方面取得的重大进展使我们能够 解决四个具体目标： 1.确定大脑的功能组织(使用功能磁共振成像) ADHD和ADHD亚组(ADHD/IT、ADHD/CT)，以确定是否 特定的大脑激活模式为特定的 在初始项目期间确定的子组。 2.确定RD共病对脑活动的影响 模式(比较ADHD无RD和ADHD伴RD)。 3.确定药物治疗对脑激活的影响 模式：a)在ADHD亚组内，b)在儿童群体之间 ADHD和RD并存，即ADHD不伴RD和ADHD伴RD。 4.将fMRI确定的大脑激活模式与变化联系起来 在认知(特别是注意力和语言)过程中 比较：a)ADHD与正常；b)在ADHD(ADHD)亚组内 注意力不集中VS ADHD混合型)；c)伴和不伴RD的ADHD；d) 药物治疗的效果。

Project I will examine the neurobiological underpinnings of Attention- Deficit/Hyperactivity Disorder (ADHD), using functional magnetic resonance imaging (fMRI) to study children recruited in the initial Center program. Specifically, children initially assessed at 7.5-13.3 years will be systematically re-evaluated at ages 11-16 years. The sample and the significant progress made by our research group in using fMRI allow us to address four specific aims: 1. To determine the functional organization of the brain (using fMRI) in ADHD and within subgroups of ADHD (ADHD/IT, ADHD/CT), to determine whether particular brain activation patterns provide a "signature" for specific subgroups identified during the initial project period. 2. To determine the influence of comorbidity with RD on brain activation patterns (comparing ADHD without RD and ADHD with RD). 3. To determine the effects of pharmacotherapy on brain activation patterns: a) within subgroups of ADHD and b) between groups of children comorbid for ADHD and RD, i.e., ADHD without RD and ADHD with RD. 4. To relate brain activation patterns as determined with fMRI to changes in cognitive (particularly attentional and linguistic) processes comparing: a) ADHD with normals; b) within subgroups of ADHD (ADHD Inattentive vs ADHD combined type); c) ADHD with and without RD; d) effects of pharmacotherapy.