GENETIC ANALYSIS OF HEREDITARY NONSYNDROMIC ORAL CLEFTS

这个项目是在上一个财政年度开始的。它 包括收集临床信息和血液样本， 在叙利亚的高度近亲繁殖的家庭中， 唇腭裂的危害有哪些？合作 叙利亚当地的调查人员和一个月的访问叙利亚博士。 Wyszynski已经收集了20多个大型谱系 适合于通过纯合性技术进行连锁分析 映射.正在收集数据。A 10 cM纯合性 已完成基因扫描绘图，但没有阳性结果。 与JHUSPH的Terri Beaty博士的合作已经启动 以增加功率。我们从叙利亚采集的样本将在 和贝蒂医生一起沿着的CIDR从其他几个地点采集的样本， 将在会议期间进行协作联系分析， 即将到来的财政年度。

This project was begun in the previous fiscal year. It involves collection of clinical information and blood samples for genotyping in highly inbred families in Syria from families with many members affected with cleft lip and palate. Cooperation with Syrian local investigators and a month long visit to Syria by Dr. Wyszynski have resulted in collection of over 20 large pedigrees suitable for linkage analysis by the technique of homozygosity mapping. Data collection is ongoing. A 10 cM homozygosity mapping genome scan has been completed with no positive results. A collaboration with Dr. Terri Beaty of JHUSPH has been initiated to increase power. Our samples from Syria will be genotyped at CIDR along with Dr. Beaty?s samples from several other sites and collaborative linkage analyses will be performed during the upcoming fiscal year.