Auditory Cognition in Alzheimer's Disease

为了创建预测和诊断痴呆症的测试，了解记忆和思维问题是如何发展的很重要。听力损失可能与痴呆症的发展有关，测试听力可以帮助预测和诊断这种情况。我想知道听力损失对记忆和思维的影响是否是由于人们记住声音的能力出现问题。这被称为听觉工作记忆（简称AWM）。例如，当我们试图在嘈杂的房间里进行对话并正确识别说话者的话时，AWM非常重要。AWM的问题可能意味着人们的听力很差，即使他们在常规听力测试中有很好的结果。我将通过扫描患有和未患有阿尔茨海默病的人的大脑来检查AWM的大脑网络，以找出是否存在可以解释为什么会出现记忆和思维问题的差异。我将看：1。阿尔茨海默病患者是否有AWM2问题。AWM的问题是否与大脑中海马体的变化有关，海马体对记忆至关重要，在阿尔茨海默病的早期也会受到影响。该项目将为进一步的大规模研究提供基础，在这些研究中，人们的AWM表现将随着时间的推移而得到评估，以展示该测试如何用于在疾病过程的早期识别患有阿尔茨海默病的人。

To create tests to predict and diagnose dementia, it is important to understand how problems with memory and thinking develop. Hearing loss may be involved in how dementia develops, and testing hearing could help to predict and diagnose the condition. I want to find out whether the effects of hearing loss on memory and thinking are due to problems with people's ability to hold sounds in mind. This is called auditory working memory (AWM for short). For example, AWM is very important when we are trying to have a conversation in a noisy room and identify the speaker's words correctly. Problems with AWM can mean that people have poor hearing, even though they have good results on conventional hearing tests.I will examine the brain network for AWM by scanning the brains of people with and without Alzheimer's disease, to find out if there are differences that can explain why problems with memory and thinking occur. I will look at:1. Whether people with Alzheimer's disease have problems with AWM2. Whether problems with AWM are linked to changes in a part of the brain called the hippocampus, which is crucial for memory, and is also affected early in Alzheimer's disease.This project will provide the basis for further large-scaled studies where people's AWM performance is assessed over time to show how this test can be used to identify people with Alzheimer's disease early in the disease course.