Transmission, pathogenesis and immunogenicity of SARS-CoV-2 in frontline healthcare workers: a national longitudinal cohort of 1320 participants

我们想知道有多少医生和护士感染了导致新冠肺炎的病毒(SARS-Cov2)，无论是否有症状。在大流行期间，我们每周都会采集1320名医护人员的血液。我们正在分析血液中的病毒抗体。我们将继续对他们的血液进行10次检测，直到封锁解除后的6个月。这项研究还将让我们知道血液中的抗体水平如何随着时间的推移而变化，以及哪些抗体能够对抗病毒。我们将调查包括遗传、年龄、性别、种族在内的个人特征是否会影响抗体在血液中保持足够高的水平以对抗病毒的时间长度。在我们研究的医生和护士中，有严重感染的人，其他人有轻微症状，许多人没有症状。我们将把所有这些信息放在一起，以确定医护人员是如何产生针对病毒的抗体的，如果这受到症状严重程度的影响，这一点很重要。我们将测量蛋白质和基因表达，以确定如何有效地接种疫苗和治疗医护人员。

We want to know how many and which doctors and nurses have been infected with the virus (SARS-Cov2) that causes COVID-19 with or without symptoms. We have been collecting blood from 1320 healthcare workers on a weekly basis during the pandemic. We are analysing blood for antibodies against the virus. We will continue to measure their blood 10 times up to 6 months after the lockdown is lifted.This study will also allow us to know how the levels of antibodies in blood change over time and which of the antibodies are able to fight the virus. We will investigate whether individual characteristics, including genetics, age, sex, ethnicity, affect the length of time for which antibodies remain in blood at high enough levels to fight the virus. Among the doctors and nurses in our study we have people who have had a severe infection, others who have had mild symptoms and many with no symptoms. We will put all this information together to work out how healthcare workers develop antibodies against the virus and if this is affected by the severity of the symptoms is important. We will measure proteins and gene expression to identify how to effectively vaccinate and treat healthcare workers.