Development of novel anti-cancer agents based on cytochrome P450-mediated epoxides of omega-3 fatty acids

对于晚期乳腺癌，几乎没有有效的治疗方法。膳食中ω-3和ω-6脂肪酸分别降低和增加癌症扩散的风险。我们发现ω-3脂肪酸环氧化物代谢物能抑制肿瘤细胞的生长，并在乳腺癌动物模型中制备了具有高度体内活性的类似物。这个项目将改进和优化这些药物，这些药物有望成为一类新的抗癌药物，有可能治疗晚期疾病。

There are few effective treatments for advanced breast cancer. Dietary ω-3 and ω-6 fatty acids respectively decrease and increase the risk of cancer spread. We have found that ω-3 fatty acid epoxide metabolites inhibit the growth of tumour cells and have prepared analogues that are highly active in vivo in animal models of breast cancer. This project will improve and optimise these agents that hold promise as a new class of anti-cancer drugs with the potential to treat advanced disease.