ENDOSCOPIC SPHINCTEROTOMY FOR SPHINCTER OF ODDI DYSFUNCTION

内镜下括约肌切开术（ES）已被证明是缓解Oddi括约肌功能障碍患者胆汁型疼痛的有效治疗方法，Oddi括约肌功能障碍定义为内镜下逆行胆管造影术（ERC）时基线括约肌压力升高。 最近的研究表明，Oddi括约肌测压在预测ES反应方面既不是100%敏感，也不是100%特异;此外，ES在临床括约肌功能障碍和正常测压患者中的疗效在很大程度上尚未研究。我们认为，在以前未研究的患者人群中，与假括约肌切开术相比，内镜下括约肌切开术将显著缓解疼痛并改善生活质量。

Endoscopic sphincterotomy (ES) has been shown to be an effective treat- ment for relieving biliary-type pain in patients with sphincter of Oddi dysfuntion defined by elevated baseline sphincter pressures at the time of endoscopic retrograde cholangiography (ERC). Recent studies suggest that sphincter of Oddi manometry is neither 100% sensitive nor specific in predicting response to ES; further the efficacy of ES in patients with clinical sphincter dysfunction and normal manometry is largely unstudied. We theorize that endoscopic sphincterotomy will result in significant pain alleviation and improved quality of life when compared to sham sphincterotomy in this previously unstudied patient population.