HUMAN PROLACTIN SECRETION IN VARIOUS ENDOCRINE DISORDERS

催乳素水平测定在患者垂体功能障碍在动态挑衅刺激。重点是催乳素分泌垂体腺瘤患者，术前和术后腺瘤切除术。高泌乳素血症和垂体功能低下的患者也在该方案下进行研究。后一组的动态研究可能有助于确定这些患者垂体功能减退的机制。催乳素动态研究在预测经蝶窦手术对分泌催乳素的垂体腺瘤患者的长期疗效方面的有用性的数据发表于1986年。催乳素水平在垂体功能低下相关的功能性或非功能性腺瘤患者中经常升高。我们的研究表明，在这些情况下，催乳素水平升高的程度与减压手术后垂体功能恢复的潜力相关。我们正在将催乳素分泌的动态数据与同一患者催乳素分泌脉动方面的评估数据进行比较和对比。长期随访的患者手术切除垂体腺瘤10至25年前，正在评估。我们的一个主要优势是跟踪了相对较多的患者，使我们能够进行这些长期研究。

Prolactin levels are determined in patients with pituitary dysfunction during dynamic provocative stimulation. The emphasis is on patients with prolactin secreting pituitary adenomas, pre and post surgical adenomectomy. Patients with hyperprolactinemia and hypopituitarism are also being studied under this protocol. The dynamic studies in the latter group is likely to help define the mechanism of hypopituitarism in these patients. The data documenting the usefulness of prolactin dynamic studies in predicting the long term benefit from transsphenoidal surgery in patients with prolactin secreting pituitary adenomas were published in 1986. Prolactin levels are often elevated in patients with functioning or non functioning adenomas associated with hypopituitarism. Our study has demonstrated that the degree of prolactin level elevation under these situations, correlate with the potential for recovery of pituitary function after decompressive surgery. We are in the process of comparing and contrasting data on the dynamics of prolactin secretion with that obtained from evaluating the pulsatile aspect of prolactin secretion in the same patients. The long term follow up of patients who had surgical resection of pituitary adenomas 10 to 25 years ago, is being assessed. We have a major advantage in following a relatively large number of these patients to allow us to do these long-term studies.