DIFFUSION TENSOR MEASUREMENT OF GUINEA PIG LUNG AIRWAYS USING HYPERPOLARIZED

肺气道的弥散张量将用 超极化(HP)3He气体。到目前为止，扩散张量测量 在肺中都是不可行的，因为使用 质子。据估计，各向异性到各向异性的转变 将确定肺气道结构的各向同性。这个 扩散张量将使用一种基于最近的 在心肌纤维图谱方面所做的工作(E.W.Hsu等人)。 DIRECT磁共振心肌纤维定向图 组织学上的相关性。AJP心脏和循环生理学274， 1627-34(1998))。多张照片将在不同的地点拍摄 渐变值(b值)和6种不同的渐变组合。

The diffusion tensor of lung airways will be measured using hyperpolarized (HP) 3He gas. To date, diffusion tensor measurements in the lung have not been viable due to the very low SNR achieved with protons. It is estimated that the changeover from anisotropy to isotropy in the lung airway structure will be determined. The diffusion tensor will be measured using a technique based on recent work done in fiber mapping of cardiac muscle (E. W. Hsu et al. Magnetic resonance myocardial fiber orientation mapping with direct histological correlation. AJP Heart and Circulatory Physiology 274, 1627-34 (1998)). A number of images will be taken at different gradient values (b-values) and in 6 different gradient combinations.