MRC National Survey of Health and Development (NSHD, 1946 British Birth Cohort).

研究背景目前有920万人，占英国人口的14%，年龄在70岁以上；这些数字将在未来十年迅速增长。预期寿命的增长停滞不前，健康状况不佳的年数有所增加。痴呆症是造成老年依赖的一个重要因素，已超过心血管疾病，成为最常见的死亡原因。这些趋势将大大增加已经捉襟见肘的卫生和社会保健服务的压力。迫切需要研究找到改善整个生命健康老龄化的方法。1946年出生的5362名新生儿的MRC NSHD被描述为队列中“皇冠上的宝石”；它是世界上持续运行时间最长的出生队列，也是英国最古老的出生队列。它在解决MRC战略交付计划“促进健康老龄化和减少一生中精神和身体疾病的负担”、UKRI战略主题“确保更好的健康、老龄化和福祉”以及PRUK最大限度地发挥数据潜力方面具有独特的地位。在27次扫描中，超过2500名参与者接受了随访我们进行了广泛的生物医学，社会经济，认知和身体检查。生物样本如血液、尿液、唾液和脑脊液被储存起来。已获得老年人重复脑和心脏成像以及长期可穿戴和远程数据，并持续同意器官捐赠。这些多样化和复杂数据的处理、存储、发现和访问基础设施将确保这一宝贵资源的长期遗产。参与者称自己为“道格拉斯孩子”，以NSHD的创始人詹姆斯·道格拉斯的名字命名，反映了他们对这项研究的终身承诺。这反映在对正在进行的数据收集（70-80%）的一贯高反应率上，包括问卷调查、强化临床亚研究、腰椎穿刺（30%）和器官捐赠（30%）。这些异常高的反应率可以与年轻队列的低得多的反应率形成对比。伦敦大学学院的纵向研究中心（CLS）策划了所有连续的国家出生队列（1958年、1970年和2000年）。我们与CLS的结盟将统一数据处理和访问合并的国家出生队列资源。目的：我们将显著增加NSHD数据资源的多学科使用，以了解和告知整个生命的健康和福祉。为了实现这一目标，我们将提高对丰富的整个生命数据的可见性和可访问性，通过国家记录链接加强这一点，并确保参与者继续参与研究。目的实现NSHD数据与健康和行政记录的联动。加速使用复杂和重复的可穿戴、远程测试、多组学和成像数据。确保77年的历史和持续数据符合数据和生物样本可发现性、可访问性和可用性的最佳现行实践标准，供广泛的多学科研究人员使用。通过CLS建立所有国家出生队列数据的单一“前门”，建立共同的数据流程并加速生物医学和社会科学界对所有5个国家出生队列的使用。保持参与者的参与度。测试不同的低强度数据收集方法，为日后的拨款申请提供依据。应用和收益加速跨多个学科独特的NSHD资源的使用，通过链接，使临床结果研究成为可能。生成工具，从复杂的可穿戴、远程、成像和多组学数据更多地部署所有国家出生队列，以解决政策问题在所有国家出生队列中收集新数据的一致性为在更年轻的国家出生队列中收集更多生物医学数据奠定基础对成年健康高峰的发展，中年维持和成功老龄化的新见解。

Research contextCurrently 9.2 million people, 14% of the UK population, are aged over 70; these numbers will grow rapidly over the next decade. Increases in life expectancy have stalled, and number of years lived in poor health has increased. Dementia, a significant contributor to old age dependency, has overtaken cardiovascular disease as the commonest cause of death. These trends will substantially increase pressure on already stretched health and social care services. Research is urgently needed to find ways of improving healthy ageing throughout life. The MRC NSHD of 5362 births in 1946 is described as the 'jewel in the crown' of cohorts; it is the longest continually running birth cohort in the world and the oldest of the UK national birth cohorts. It is uniquely placed to address the MRC Strategic Delivery Plan on "promoting healthy ageing & reducing the burden of mental and physical illness throughout life", the UKRI strategic theme of "securing better health, ageing & wellbeing" and PRUK's scope to maximise data potential. Over 2500 participants are in follow up, from 27 sweeps we have extensive biomedical, socioeconomic, cognitive, and physical measures. Biological samples such as blood, urine, saliva and CSF are stored. Repeat brain and cardiac imaging & long term wearable and remote data have been acquired in older age, with ongoing consent for organ donation. Processing, storage, discovery and access infrastructures for these diverse and complex data will secure the long-term legacy of this precious resource. Participants refer to themselves as the 'Douglas children', named after James Douglas who founded the NSHD, reflecting their lifelong commitment to the study. This is reflected by consistently high response rates to on-going data collections (70-80%) which include questionnaires, intensive clinical sub-studies, lumbar puncture (30%), & organ donation (30%). These exceptionally high responses rates can be contrasted with the much lower response rates in the younger cohorts.The Centre for Longitudinal Studies (CLS) at UCL curates all successive national birth cohorts (1958, 1970 and 2000). Our alignment with CLS will unify data processes and access to the combined national birth cohort resource. AimsWe will markedly increase the multidisciplinary use of the NSHD data resource to understand and inform on health and wellbeing throughout life. To achieve this we will improve visibility of and access to the rich whole of life data, enhance this with national record linkage and ensure continued participant engagement with research.ObjectivesTo enable linkage of NSHD data to health and administrative records.To accelerate use of complex and repeat wearable, remote testing, multi-omic and imaging data.To ensure the 77 years' of historical and ongoing data meet best current standards of practice for data and biosample discoverability, access and usability by a broad base of multidisciplinary researchers. To establish a single 'front door' to all national birth cohort data with the CLS, establishing common data processes and accelerating use of all 5 national birth cohorts by the biomedical and social science community. To maintain participant engagement.To test out different ways of low intensity data collection to inform future grant applications.Applications and benefitsAccelerate the use of the unique NSHD resource across multiple disciplinesWith linkage, enable study of clinical outcomes Generation of tools to extract analysis-ready variables from complex wearable, remote, imaging and multi-omic dataGreater deployment of all national birth cohorts together to address policy questions Alignment of new data collection across all national birth cohorts Set the foundation for greater biomedical data collection in the younger national birth cohortsNovel insights into the development of peak health adulthood, maintenance in middle age and successful ageing.