METHAMPHETAMINE DEPENDENCE AND THE RISK OF HIV INFECTION

描述：(申请人摘要) 美国对甲基苯丙胺(MA)的依赖正在迅速扩大， 回顾1950年S和1960年S疫情传播的早期阶段。 超越与上瘾直接相关的发病率和死亡率 鉴于艾滋病毒的流行，MA特别令人关注，因为它 通常是静脉给药，它通常会增强性欲。这 性和注射吸毒(IDU)危险因素的汇合导致 使用MA人群中的高HIV血清阳性率。 尽管对MA的依赖迅速增加，但人们对其天然情况知之甚少 性行为和吸毒者的历史和相对贡献 艾滋病毒传播的风险。在对并购依赖的纵向研究中，我们将 使用一系列全面的评估来确定高血压的预测因素 危险行为；各种性和吸毒因素的相对贡献 对艾滋病毒血清阳性；艾滋病毒血清转换率；风险变化 药物治疗后的行为和MA使用情况； 精神疾病共病的稳定性。受试者将从 旧金山海特·阿什伯里脱毒中心以同性恋为主的门诊人群 弗朗西斯科，来自以异性恋为主的门诊人口 在萨克拉门托的努力，以及旧金山的非治疗MA用户 还有萨克拉门托。

DESCRIPTION: (Applicant's Abstract) Methamphetamine (MA) dependence is expanding rapidly in the United States, recapitulating early phases of epidemic spread in the 1950's and 1960's. Beyond the morbidity and mortality directly associated with addictive disease, MA is of particular concern in light of the HIV epidemic because it is often administered intravenously and it often increases libido. This confluence of sexual and injection drug use (IDU) risk factors has led to high HIV seroprevalence in MA using populations. Despite the rapid increase in MA dependence, little is known of its natural history and the relative contributions of sexual and IDU behaviors to the risk of HIV transmission. In a longitudinal study of MA dependence, we will use a comprehensive battery of assessments to identify predictors of high risk behaviors; the relative contributions of various sexual and IDU factors to HIV seropositivity; rates of HIV seroconversion; changes in risk behaviors and MA use following drug treatment; and the prevalence and stability of psychiatric comorbidity. Subjects will be recruited from the largely homosexual outpatient population at Haight Ashbury Detox in San Francisco, from predominately heterosexual outpatient population at The Effort in Sacramento, and from out-of-treatment MA users in San Francisco and Sacramento.