Diabetes exacerbates non-alcoholic steato-hepatitis (NASH)

非酒精性脂肪性肝炎(NASH)是一种常见的肝脏炎症和瘢痕形成疾病，可发展为肝硬变或肝癌。虽然2型糖尿病导致更高的NASH发生率和更快的NASH进展，但其原因尚不清楚。我们开发了一种新的NASH动物模型，并在饮食诱导肥胖的基础上增加了糖尿病。我们发现，受影响的肝脏中有一种生长因子升高。我们计划阻断增长因素，看看能否防止纳什恶化。

Non-alcoholic steato-hepatitis (NASH) is a common disease of liver inflammation and scarring, which may progress to cirrhosis or liver cancer. While type 2 diabetes causes a higher rate of NASH and more rapid NASH progression the reasons for this are not clear. We have developed a novel animal model of NASH with diabetes added to dietary induced obesity. We show that a growth factor is elevated in the affected livers. We plan to block the growth factor to see if we can prevent NASH worsening.