DYNAMIC PATTERN IN CHEMICALLY REACTING SYSTEM

描述(逐字摘自调查人员摘要)：长距离 这项研究的目的是加深我们对动力学的理解 相互作用的细胞聚集体的行为，并将这一知识应用于 发育生物学中的细胞运动和模式形成问题 生理学上的问题。主要项目有：(1)模式研究 发育中的形成，(2)细菌信号转导的研究， 趋化性与花纹形成；(3)钙动力学研究 在神经胶质细胞中。在(1)项下的目的是研究在模型中的模式形成 一个正在生长的肢体，并分析新的图案形成和细胞模型 盘基网眼藻的运动。第(2)款下的目标是发展和 分析一个控制大肠杆菌中鞭毛马达的模型，以将其用于 模拟细菌的运动，分析运动的随机模型 种群水平，并研究不断增长的群体中格局的形成。这个 第(3)项下的目标是开发钙动力学模型 在神经胶质细胞中，并研究空间异质性的通道和 随机通道开放在钙波启动中的作用 通过直接和间接途径进行的细胞间通讯 波的类型及其传播的幅度、宽度和范围。这项研究 (1)将增进我们对发展中的基本过程的理解 生物学，如信号转导、细胞和组织运动以及模式 队形。更好地理解这些基本过程将 有助于更好地了解系统如何响应其 环境，正常的发展如何被扰乱，甚至可能是异常的 已更正的发展，以及免疫系统的某些组件是如何 功能。(2)中的工作结果将有助于我们理解 细胞外信号是如何在细菌中转导到运动控制中的，是如何 个体的微观行为反映在种群水平上 描述，以及营养供应和趋化因子如何控制模式 队形。(3)中的工作将导致对钙的更好的理解 神经胶质细胞的动力学，从而将促进我们对神经的理解 发展、癫痫和神经退行性疾病。

DESCRIPTION (appended verbatim from investigator's abstract): The long range objectives of this research are to further our understanding of the dynamical behavior of aggregates of interacting cells, and to apply this knowledge to problems of cell movement and pattern formation in developmental biology and to problems in physiology. The major projects are: (1) studies on pattern formation in development, (2) studies on bacterial signal transduction, chemotaxis and pattern formation, and (3) studies on calcium dynamics in glial cells. The aims under (1) are to study pattern formation in models of a growing limb and to analyze new models for pattern formation and cell movement in Dictyostelium discoideum. The aims under (2) are to develop and analyze a model for control of the flagellar motor in E. coli, to use this in simulation of bacterial motion, to analyze stochastic models of motion at the population level, and to study pattern formation in growing colonies. The objectives under (3) are to develop models of calcium dynamics in glial cells and to study the role of spatial heterogeneity of channels and stochastic channel openings in the initiation of calcium waves, and the role of intercellular communication via direct and indirect pathways in determining the type of wave and its amplitude, width, and range of propagation. The research in (1) will advance our understanding of basic processes in developmental biology such as signal transduction, cell and tissue motion, and pattern formation. A better understanding of these fundamental processes will contribute to a better understanding of how systems respond to their environment, how normal development can be disrupted and perhaps abnormal development corrected, and how certain components of the immune system function. The results of the work in (2) will contribute to our understanding of how extracellular signals are transduced into motor control in bacteria, how the microscopic behavior of individuals is reflected in population level descriptions, and how nutrient supply and chemotactic factors control pattern formation. The work in (3) will lead to a better understanding of calcium dynamics in glial cells, and will thereby advance our understanding of neural development, epilepsy and neuro degenerative diseases.