TISSUE PERFUSION AND BLOOD FLOW MONITORING TECHNOLOGY

其目的是开发一种用于测量皮肤血流速度的实时光学成像设备。在第一阶段，开发了获取数字化血流速度的技术来监测感兴趣的区域，并通过动物模型演示了初步原型的准确性。第二阶段的具体目标包括开发先进的原型，改进第一阶段开发的算法，临床研究，设备的评估和验证，以及在第三阶段开发商业设备的关键工程问题的调查。先进的原型和算法的评估和验证将在静态和动态散斑、猪模型和人体受试者的测量上进行。潜在的创新包括开发一种用于非接触式、实时监测组织血流的集成设备，以及开发先进的血液和组织光学算法以及光学成像。利用这项技术检测组织血管结构的变化，为定期、安全和常规地监测患者提供了一种手段。这项技术有潜力评估外科手术，如皮瓣，血管疾病的治疗，糖尿病并发症的情况，肿瘤的进展和移植手术的器官状况。拟议的商业应用：新设备将提供实时、非接触的区域成像能力，而不是激光多普勒流量计提供的点状测量。商业应用包括监测患者在涉及皮瓣、手指再附着、移植和血管手术的整形和重建手术中和之后的组织活性，以及在创伤治疗过程中的组织活性。

The objective is to develop a real-time, optical imaging device for measuring skin blood flow velocities. In Phase I, the technology of acquiring digitized blood velocities was developed to monitor areas of interest and the accuracy of a preliminary prototype was demonstrated animal models. Specific aims of Phase II include the development of an advanced prototype, improvement of algorithms developed in Phase I, a clinical study, evaluation and validation of the device, and an investigation of critical engineering issues for developing the commercial device in Phase III. Evaluation and validation of the advanced prototype and algorithms will be conducted on measurements of static and dynamic speckle, a porcine model, and human subjects. Potential innovations include the development of an integrated device for noncontact, real-time monitoring of tissue perfusion and the development of advanced algoriths of blood and tissue optics and optical imaging. Detection of changes in tissue vascular structure using this technology offers a means for regular, safe, and routine monitoring of patients. This technology has potential in assessing surgical procedures such as flaps, the treatment of vascular disease, the condition of diabetic complications, the progression of tumors and the condition of organs for transplant surgery. PROPOSED COMMERCIAL APPLICATION: The new device will provide real-time, noncontact, area imaging capabilities rather than point measurements as provided by laser Doppler flowmeters. Commercial applications include monitoring tissue viability for patients during and after plastic and reconstructive surgery involving flaps, digit reattachment, transplants, and vascular surgery, and during trauma treatment procedures.