LONGITUDINAL OPTIC NEURITIS STUDY

这项建议是对这一队列进行长期随访研究， 入组视神经炎治疗试验（ONT）的患者 在1988年至1991年期间， 自1992年以来的视神经炎研究（隆恩）。 ONT的主要目标是 评价皮质类固醇治疗急性视神经病变的疗效， 神经炎 隆恩的主要目标是（1）评估 视神经炎后视功能的长期病程和（2） 视神经炎与多发性硬化关系的探讨 硬化症（MS）。 本申请旨在延续“长期隆恩”， 获得更多有价值的长期随访信息， 视觉过程和神经过程在这个独特的患者队列。 没有其他研究曾经如此广泛地收集和评估， 标准化的方法，这样一个大量的患者与光学 神经炎 这支队伍是通过相当大的努力和成本组建起来的。 目前拟议的研究所涉费用与 总的研究费用。 从这项研究中产生的信息将有 与视神经病变患者的治疗和生活质量相关 神经炎 在该提案的前四年，患者接触将是 通过电话和邮件从数据协调 中心 第五年，15家隆恩诊所将重新获得认证并 每个病人都将接受眼部检查， 测试和神经系统检查的协议，目前使用的 隆恩。 此次访视将与每个患者10-13年的随访同时进行。 病人 主要手稿计划用于眼科和 神经学结果 超过90%的原始队列仍在随访和机制中 确保这一高比率将继续下去， 长期研究的有效结果。

This proposal is to conduct a long-term follow-up study of the cohort of patients who were entered into the Optic Neuritic Treatment Trial (ONTT) between 1988 and 1991 and have been followed as part of the Longitudinal Optic Neuritis Study (LONS) since 1992. The ONTT's primary objective was to assess the efficacy of corticosteroids in the treatment of acute optic neuritis. The LONS' primary objectives are (1) the evaluation of the long-term course of visual function after optic neuritis and (2) investigation of the relationship between optic neuritis and multiple sclerosis (MS). This application is for a continuation of the LONS to acquire additional valuable long-term follow-up information about both the visual course and the neurologic course in this unique patient cohort. No other study has ever assembled and evaluated so extensively with standardized methodology such a large number of patients with optic neuritis. The cohort was assembled through considerable effort and cost. The costs involved in the current proposed study are small compared to the overall study costs. The information emanating from this study will have both therapeutic and quality of life relevance for patients with optic neuritic. For the first four years of the proposal, patient contact will be maintained through phone calls and mailings from the Data Coordinating Center. In the fifth year, the 15 LONS clinics will be recertified and each patient will be seen for an ocular examination, visual function testing, and neurologic examination by protocols currently utilized in the LONS. This visit will coincide with 10-13 years of follow-up for each patient. Major manuscripts are planned for both the ophthalmic and neurologic results. More than 90% of the original cohort remains in follow-up and mechanisms are in place to assure that this high rate will continue so as to provide valid results for the long-term study.