MODERATE ALCOHOL USE & HEALTH: PREFERENCES & OUTCOMES

该提案寻求指导以患者为导向的研究职业发展奖。 候选人建议利用这个奖项来促进研究事业，研究适度饮酒对特定健康措施的影响。职业发展计划的目标有四个方面：（1）发展方法学专业知识，以了解个人的个人偏好和价值观，特别是与饮酒有关的偏好和价值观;（2）获得量化行为因素对患者群体中指定健康结果的影响的经验;（3）发展决策分析的专业知识，通过结合个人偏好和结果数据为患者决策提供信息;（4）利用这些研究的结果建立研究的独立性。 在一个结构化的计划中，申请人将在哈佛公共卫生学院接受正式培训，并在波士顿贝丝以色列女执事医疗中心心脏病行为决定因素的积极调查员Murray Mittleman，MD，DrPH的监督下毕业。 这些职业发展目标与研究计划密切相关，研究计划将在连续掌握这些目标时使用它们。该研究项目的总体目标是了解个人如何看待适度饮酒的竞争风险和益处，以及这些竞争因素实际上如何影响健康。 该研究计划将包括三项相关研究：（1）开发一种调查工具，由申请人在不同的门诊环境中对患者进行管理，以确定他们对适度饮酒及其影响的偏好;（2）在心肌梗死发病决定因素研究中分析饮酒对急性心肌梗死后生存的影响;以及（3）使用冠心病政策模型评估适度饮酒对总死亡率的总体影响，使用调查结果来改进政策模型结果的适用性。

This proposal seeks a Mentored Patient-Oriented Research Career Development Award. The candidate proposes to use this award to foster a research career in the study of the effect of moderate alcohol consumption on specific health measures. The aims of the career development plan are fourfold: (1) to develop methodologic expertise in eliciting personal preferences and values from individuals, particularly related to alcohol use; (2) to gain experience in quantifying the effect of behavioral factors on designated health outcomes amongst groups of patients; (3) to develop expertise in the use of decision analysis to inform patient decision-making by combining personal preferences and outcomes data; and (4) to use the results of these studies to establish research independence. In a structured program, the applicant will receive formal training at the Harvard School of Public Health and graduated supervision from Murray Mittleman, MD, DrPH, an active investigator in the behavioral determinants of heart disease at Beth Israel Deaconess Medical Center in Boston. These career development goals closely parallel the research plan, which will employ them as they are mastered in succession. The overall aim of the research program is to understand how individuals view the competing risks and benefits of moderate alcohol consumption and how those competing factors actually influence health. The research program will comprise three related studies: (1) development of a survey instrument to be administered by the applicant to patients in different outpatient settings to determine their preferences about moderate alcohol consumption and its effects; (2) analysis of the effect of alcohol use on survival following acute myocardial infarction in the Determinants of Myocardial Infarction Onset Study; and (3) assessment of the populationwide effect of moderate alcohol use on total mortality with the Coronary Heart Disease Policy Model, using the survey results to refine the applicability of the Policy Model findings.