CORE--BIOSTATISTICS AND DATA MANAGEMENT

生物统计和数据管理核心（BDMC）在上一个资助期作为核心建立，从零开始为ADRC构建了一个功能齐全的中央数据库。在本供资期间，它扩大了生物统计咨询服务，并开始了几项合作举措。BDMC的具体目标是：1。维护来自临床核心的所有信息的综合数据库; 2.创建和维护来自其他ADRC组件和ADRC附属项目的所有信息的数据集;按照既定的数据输入和数据使用标准程序，保持输入中央数据库的所有数据的准确性和保密性; 4.制定和修改数据收集表格，以满足核心和项目中新举措的需要; 5.培训ADRC人员使用数据库; 6.向行政核心提供数据库摘要，以帮助监测患者和正常对照受试者入组和流程，并向执行委员会提供所需的这些数据库摘要，以帮助确定开展拟议研究的可行性; 7.准备提交给ADDCC（阿尔茨海默病数据协调中心）的数据，并确保其质量和完整性; 8.为核心、试点项目和其他与ADRC相关的调查人员提供实验设计、统计分析和数据管理方面的专业知识; 9.与其他ADRC核心和附属项目，其他ADRC，ADCs，ADCS和AD研究方法合作; 10.将统计方法和数据管理方面的进展纳入解释和/或分析核心数据或ADRC相关项目收集的数据，并根据需要开展开发工作; 11.参与培养研究生、博士后研究人员，并发现对AD研究感兴趣的研究人员。

Established as a core in the last funding period, the Biostatistics and Data Management Core (BDMC) has constructed from scratch a fully functional centralized database for the ADRC. It has expanded its biostatistical consulting services during this funding period and has begun several collaborative initiatives. The specific aims of the BDMC are to: 1. maintain integrated databases for all information derived from the Clinical Core; 2. create and maintain data sets for all information derived from other ADRC components and ADRC affiliated projects; 3. maintain accuracy and confidentiality of all data entered into the centralized database by standard established procedures for data entry and data use; 4. develop and modify data collection forms to meet the needs of new initiatives in the cores and projects; 5. train ADRC personnel in the use of the database; 6. provide summaries of the databases to the Administrative Core to help monitor patient and normal control subject enrollment and flow and provide requested summaries of these databases to the Executive Committee to help determine the feasibility of conducting proposed research studies; 7. prepare the data to be submitted to the ADDCC (Alzheimer's Disease Data Coordinating Center) and assure its quality and completeness; 8. provide expertise in experimental design, statistical analyses, and data management to cores, pilot projects, and other investigators affiliated with the ADRC; 9. collaborate with the other ADRC cores and affiliated projects, other ADRCs, ADCs, ADCS, and the methodologies in AD research; 10. incorporate advances in statistical methodology and data management for interpreting and or analyzing data collected by the cores or by the ADRC related projects with development work as needed; 11. participate in the training of graduate students, postdoctoral researchers, and found investigators interested in AD research.