CORE--FAMILIAL BREAST CANCER RESOURCE

我们建立家族性乳腺癌资源的主要任务是 降低乳腺癌的发病率、发病率和死亡率。对这件事 最终，该资源将用于鉴定和研究小麦的遗传标记。 乳腺癌易感性，并为高危妇女提供参与 在癌症筛查和预防试验中。 家族性乳腺癌的指标性病例是从我们自己的肿瘤中确定的 银行、医生推荐、直接媒体征集、筛查 乳房X光检查报告和其他来源。应计费用已超过我们的 原来的预测实质上是。该数据库目前包括223个 代表12,137个人的家庭，包括707个成员 乳腺癌病史。数据收集包括有详细记录的学位 扩大到包括所有乳腺癌病例的二级亲属。 数据项包括人口统计和联系信息以及临床信息 关于所有癌症和所有良性乳房疾病的信息。在.期间 在下一个资助期，我们建议把重点放在检讨和 核实临床数据和招募西班牙裔家庭的情况。 资源之间有良好的合作关系 和本地乳腺癌试验(例如NSABP乳腺癌预防试验) 这样，有家族病史的试验参与者就会被转介到 资源和资源将感兴趣的高危患者转介给 审判。 除数据库外，该资源还包括组织库。 在获得知情同意后，从KEY获取血液样本 有3名或以上受影响成员以银行身分申请银行服务的家庭成员 超低温保存的外周血淋巴细胞(PBL)和冰冻血清。这个 世行目前有113份外周血和30份血清样本 家人。另有300人已经成为目标，但还没有 抽签了。处理知情同意书和抽血的程序 在本地和外地，用于处理血液，以及所有 相关的计算机库存和跟踪系统都很好地- 已经成立了。我们建议在下一次拨款期间继续这项活动。 句号。此外，对于受影响的成员，我们将检索存档 组织样本。在本应用程序的项目4中，我们建议使用DNA 从银行的外周血淋巴细胞检测几个肿瘤抑制基因 遗传性和散发性乳腺癌。

Our primary mission in establishing the Familial Breast Cancer Resource is to reduce the incidence, morbidity and mortality of breast cancer. To this end, the resource will be used to identify and study genetic markers of breast cancer susceptibility, and to offer high-risk women participation in cancer screening and prevention trials. Index cases of familial breast cancer are identified from our own tumor bank, physician referral, direct media solicitation, screening of mammography reports, and other sources. Accruals have exceeded our original projections substantially. The database currently includes 223 families representing 12,137 individuals, including 707 members with a history of breast cancer. Data collection includes well-documented degrees expanded to include second order relatives of all breast cancer cases. Data items include demographic and contact information as well as clinical information on all cancers, and all benign breast conditions. During the next funding period we propose to place additional emphasis on review and verification of clinical data and on recruitment of Hispanic families. There is a well-established cooperative relationship between the resource and local breast cancer trials (e.g. NSABP Breast Cancer Prevention Trial) so that trial participants with a positive family history are referred to the resource and the resource refers interested high risk patients to the trial. In addition to the databases, the resource also includes tissue banks. After obtaining informed consent, blood samples are obtained from key members of families with 3 or more affected members for banking as cryopreserved peripheral blood lymphocytes (PBL's) and frozen serum. The bank currently contains 113 PBL and serum samples representing 30 families. An additional 300 individuals are already targeted but not yet drawn. Procedures for handling informed consents and drawing bloods, both locally and out of town, for processing bloods, as well as all of the associated computer inventories and tracking systems, are well- established. We propose to continue this activity during the next funding period. Additionally, for affected members, we will retrieve archival tissue samples. In Project 4 of this application we propose to use DNA from banked PBL's to examine several tumor suppressor genes implicated in both hereditary and sporadic breast cancer.