THE MOLECULAR AND CELLULAR BASIS OF BRAIN AGING

该培训计划的目标是为有前途的研究生和博士后在衰老神经生物学方面的成功事业做好准备。我们将提供有关衰老神经生物学现代概念的基础广泛的培训，特别强调在衰老的大脑中发生的细胞和分子相互作用的变化。培训教师的统一焦点是我们对理解神经系统在正常和病理条件下随年龄变化而发生的变化的反应机制的兴趣。该培训计划为不同院系的教师提供了正式的框架，他们对大脑衰老的分子和细胞基础有共同的兴趣，提供了深入的衰老培训。培训学院的重点是相互补充的：一些专注于大脑在正常衰老过程中发生的过程，另一些强调在衰老的大脑中占主导地位的神经病理疾病，还有一些使用体内和体外系统来模拟衰老的大脑。因此，受训者将从教师那里学习，他们利用广泛的最先进的方法方法来探索老龄化研究中的关键问题。在过去的资助期内，我们在招募有潜力的博士后和博士后，提供最先进的培训，并将他们安置在优秀岗位上的记录是突出的。我们的成功证明了我们在老龄化领域识别、吸引、培训和安置有前途的年轻研究人员的能力，这一点是显而易见的，因为我们的人口结构不断变化，平均寿命不断延长。正常的衰老或神经系统的病理在老年人的死亡中占很大比例。只有我们更好地了解大脑衰老的基本机制，并将其应用于老年人的治疗，我们才有希望改善后半生的生活质量。我们的能力，以吸引和培养研究生和博士后研究员，以迎接挑战的神经生物学领域的老龄化将大大提高这个培训计划。

The goal of this Training Program is to prepare promising graduate students and postdoctoral fellows for successful careers in the neurobiology of aging. We will provide broad-based training in modern concepts in the neurobiology of aging with specific emphasis on changing cellular and molecular interactions that occur in the aging brain. The unifying focus of the training faculty is our interest in understanding the mechanisms by which the nervous system responds to changes that occur with age under normal and pathological conditions. This Training Program provides the formal framework for faculty in different departments, who share a common interest in the molecular and cellular basis of brain aging, to provide in depth training in aging. The emphasis of the Training Faculty complement each other: some focus on processes that occur in the brain during normal aging, others emphasize the neuropathological diseases that predominate in the aging brain, and still others use in vivo and in vitro systems to model the aging brain. Thus, trainees will learn from faculty who utilize a broad spectrum of state-of-the-art methodological approaches to probe critical questions in aging research. During the previous granting period, our record of recruiting promising pre- and post-doctoral fellows, providing state-of- the-art training, and placing them in excellent positions is outstanding. Our success attests to our ability to identify, attract, train and place promising young investigators in the area of aging is clear due to our changing demography and the increasing average lifespan. Normal aging or pathology of the nervous system account for a large percent of deaths in the elderly. Only if we better understand the basic mechanisms that regulate the aging of the brain and apply this to the treatment of the elderly, can we hope to improve the quality of life during the latter half of the lifespan. Our ability to attract and train graduate students and postdoctoral fellows to meet the challenges in the area of neurobiology of aging will be greatly enhanced by this Training Program.