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A multi-centre, double-blind, randomised controlled trial to evaluate the efficacy of 10 valent-pneumococcal-Protein D conjugate vaccine in reducing respiratory exacerbations in children aged ? 18 months with suppurative lung disease

A multi-centre, double-blind, randomised controlled trial to evaluate the efficacy of 10 valent-pneumococcal-Protein D conjugate vaccine in reducing respiratory exacerbations in children aged ? 18 months with suppurative lung disease
一项多中心、双盲、随机对照试验，旨在评估 10 价肺炎球菌-蛋白 D 结合疫苗在减少 4 岁儿童呼吸道症状加重方面的功效。
批准号：
nhmrc : 1019904
负责人：
A/Pr Heidi Smith-Vaughan
金额：
$77.39万
依托单位：
Queensland University of Technology
依托单位国家：
澳大利亚
项目类别：
Project Grants
财政年份：
2012
资助国家：
澳大利亚
项目状态：
已结题
起止时间：
2012-01-01 至 2016-12-31
来源：
https://researchdata.edu.au/multi-centre-double-lung-disease/109989
关键词：
multicentredoubleblindrandomised

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中文摘要
翻译
儿童慢性化脓性肺病是世界范围内健康状况不佳和死亡的主要原因。儿童期反复感染导致成人肺部健康状况不佳。最常见的引起感染的微生物是不可分型的流感嗜血杆菌（NTHi）。这项研究旨在确定NTHi疫苗是否可以减少儿童反复呼吸道感染。如果是这样的话，疫苗接种可能会导致当前/未来肺部健康的大幅改善，并节省相当多的直接和间接疾病成本。
英文摘要
Chronic suppurative (ie infected) lung diseases in children are major causes of poor health and deaths worldwide. Repeated childhood infections contribute to poor lung health in adults. The most common organism causing infection is non-typeable Haemophilus influenzae (NTHi). This study aims to determine whether a vaccine against NTHi can reduce repeated respiratory infections in children. If so, vaccination may lead to substantial improvements in current/ future lung health, and considerable direct and indirect cost of disease savings.
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Preventing early-onset pneumonia in Indigenous infants through maternal immunisation: a multi-centre randomised controlled trial
  • 批准号：
    nhmrc : 1138555
  • 项目类别：
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  • 资助金额：
    $217.08万
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    $51.05万
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Pneumococcal conjugate vaccine (PCV) schedules for the Northern Territory (NT): randomised controlled trial of booster vaccines to broaden and strengthen protection from invasive and mucosal infections.
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    nhmrc : 1046999
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