HOMOCYST(E)INE RESPONSE TO CEREAL FORTIF W/ FOLIC ACID

大量的观察性研究表明， 总血浆（tHCY）是动脉粥样硬化的独立危险因素。 闭塞性疾病，并与静脉血栓形成有关， 肺栓塞 此外，我们还报告说，实验 非人灵长类动物中tHCY的升高显示乙酰胆碱诱导的 动脉舒张，表明升高的tHCY改变了血管 功能 在大多数情况下，升高的tHCY水平降低， 通过补充叶酸治疗。 1998年1月1日，由于 如已知可降低神经管缺陷风险的叶酸 (NTD)在发育中的胎儿中，FDA建议 某些食物中的叶酸含量降低了100 g/天。 此外，为了测试 这个假设是全国范围内的食品强化叶酸 Malinow等人进行了一项临床试验， 添加了不同水平叶酸的早餐麦片。 结果表明，这些谷物含有叶酸（499？g和 655？g/30 g谷物）在患有以下疾病的受试者中同样降低了tHCY： 冠心病，这表明~400？叶酸的摄入量 最大限度降低tHCY。 上述研究将确定是否 叶酸强化（40？g/天）具有类似的效果， 补充剂（2.5 mg/天）。 在元分析中， 每天补充0.5至5.0毫克的叶酸 对tHCY水平的类似影响。 Homocyst（e）ine检测基金 出版物

Numerous observational studies have shown that an elevated level of total plasma (tHCY) is an independent risk factor for arterial occlusive disease, and is associated with venous thrombosis and pulmonary embolism. Moreover, we have reported that experimental elevation of tHCY in nonhuman primates shows acetycholine-induced arterial relaxation, indicating that elevated tHCY alters vascular function. In the majority of cases, elevated tHCY levels are lowered by treatment with supplemental folic acid. On January 1, 1998, due to such folic acid as known to reduce the risk for neural tube defects (NTD) in the developing fetus, the FDA recommended the fortification of certain foods with folic acid by ~100 ?g/day. Further, to test this hypothesis that nationwide fortification of food with folic acid might reduce tHCY, Malinow et al. conducted a clinical trial using breakfast cereal fortified with different levels of folic acid. Results indicated that such cereals containing folic acid (499 ?g and 655 ?g per 30 g of cereal) lowered similarly tHCY in subjects with coronary heart disease, suggesting that ~400 ?g of folic acid provides maximum effect to lower tHCY. The above study will determine whether folic acid fortification (40 ?g/day) has similar effects as supplementation (2.5 mg/day). In a metanalysis, it has been shown that folic acid supplementation between 0.5 and 5.0 mg/day have similar effects on tHCY levels. FUNDING Homocyst(e)ine testing funds PUBLICATIONS None