INSULIN HPN & REGULAR PREMIX RATIO 50 & 50 VS PREMIX RATIOS 70 & 30

本研究将研究每5单位常规胰岛素含5单位NPH的预混胰岛素制剂（50/50）和（70/30）胰岛素制剂之间的差异。 将在健康男性中进行两次12小时正葡萄糖钳夹程序。 受试者将以设盲方式皮下注射0.2单位的50/50或70/30胰岛素制剂。 将以滴定的剂量输注20%葡萄糖以维持正常。 主要疗效指标是注射后前4小时内维持正常血糖所需的葡萄糖输注速率差异。

This study will investigate differences between a premixed insulin preparation containing 5 units NPH for every 5 units regular insulin (50/50) and a (70/30) insulin preparation. Two 12 hour euglycemic clamp procedures will be performed in healthy men. Subjects will receive 0.2 units subcutaneously of the 50/50 or 70/30 insulin preparation in a blinded manner. Twenty percent dextrose will be infused at a dose titrated to maintain euglycemia. The primary efficacy measure will be the difference in glucose infusion rates required to maintain euglycemia during the first 4 hours after injection.