PARTIAL LIQUID VENTILATION IN NEONATES WITH CONGENITAL DIAPHRAGMATIC HERNIA

本研究的基本假设是利用部分液体通气法(PLV)进行肺管理将减少先天性横隔疝(CDH)新生儿所需的机械通气时间。第二个假设包括：1)与气体通气(GV)相比，接受PLV治疗的患者更少达到体外生命支持的标准；2)与GV相比，PLV治疗的新生儿CDH患者的存活率将提高；3)与GV管理的新生儿CDH患者相比，PLV管理的新生儿CDH患者的气体交换增加；4)PLV期间全身血流动力学将保持不变或改善；5)与GV相比，PLV期间应用CDH的新生儿患者的静态肺顺应性将增加。

The primary hypothesis of this study is that pulmonary management utilizing partial liquid ventilation (PLV) will result in a reduction in the required time of mechanical ventilation in neonatal patients with congenital diaphragmatic hernia (CDH). The secondary hypothesis include: 1) that patients who are managed with PLV will meet criteria for extracorporeal life support less frequently when compared with those managed with gas ventilation (GV); 2) the survival rate will be increased in those patients treated with PLV when compared to GV; 3) gas exchange will increase in neonatal patients with CDH managed with PLV when compared to those managed with GV; 4) systemic hemodynamics will be unaltered or improved during PLV; 5) static pulmonary compliance will increase in neonatal patients wiht CDH during PLV when compared to GV.