PARTIAL LIQUID VENTILATION IN NEONATES WITH CONGENITAL DIAPHRAGMATIC HERNIA

这项研究的主要假设是肺管理 使用部分液体通风(PLV)将导致减少 新生儿慢性阻塞性肺疾病机械通气所需时间的探讨 先天性横隔疝(CDH)。 第二个假设包括：1)接受治疗的患者 PLV将满足体外生命支持(ECLS)较少的标准 经常与使用气体通风(GV)管理的管理相比；2) 接受PLV治疗的患者的存活率将会提高。 与GV相比，新生儿的气体交换增加 与使用GV管理的CDH相比，使用PLV管理的CDH；3) 全身性血流动力学在PLV期间不会改变或改善；4)静态 新生儿CDH患者肺顺应性增加 PLV与GV相比。 到目前为止，我们已经在CHOP招募了7名患者。其中，有三个是 随机分为PLV组和常规治疗组各4例。我们见证了 接受PLV治疗的患者的依从性有所改善，但所有7名患者 患者需要使用ECMO。

The primary hypothesis of this study is that pulmonary management utilizing partial liquid ventilation (PLV) will result in a reduction in the required time of mechanical ventilation in neonatal patients with congenital diaphragmatic hernia (CDH). The secondary hypotheses include: 1) that patients who are managed with PLV will meet criteria for extracorporeal life support (ECLS) less frequently when compared with those managed with gas ventilation (GV); 2) the survival rate will be increased in those patients treated with PLV when compared to GV; 3) gas exchange will increase in neonatal patients with CDH managed with PLV when compared to those managed with GV; 3) systemic hemodynamics will be unaltered or improved during PLV; 4) static pulmonary compliance will increase in neonatal patients with CDH during PLV when compared to GV. To date we have enrolled 7 patients at CHOP. Of these, three were randomized to PLV and 4 received conventional therapy. We have witnessed improved compliance in the patients who have received PLV, but all 7 patients have required ECMO.