PARTIAL LIQUID VENTILLATION WITH AP0141 IN TERM INFANTS WITH SEVERE LUNG DIS

本研究的主要目的是比较传统的通风方式。 根据血气变化判断部分液体通气的治疗 (Pa02、PaC02、BE)和肺功能 延长干预期。次要目标是拥有 调查人员在以下情况下报告死亡或出院时间 液体安装开始。幸存者的人数将被报告 也是。 到目前为止，已经登记了两名婴儿，一名不到1公斤，另一名 不到2公斤。两名患者都被随机分配到部分液体组 通风。两人的呼吸在4小时内都有显著改善。 在开始治疗之后。唯一的副作用是一过性高分泌。 无论是在疗程后期还是在治疗后， 停产。

The primary objective of this study is to compare conventional ventilation therapy to partial liquid ventilation as measured by changes in blood gas values (Pa02, PaC02, BE) and pulmonary function during the acute and extended intervention periods. The secondary objective is to have the investigators report time to death or discharge from the ICU after beginning of liquid installation. The number of survivors will be reported as well. Two infants have been enrolled thus far, one less than 1 kg and the other less than 2 kg. Both patients were randomized to partial liquid ventilation. Both had dramatic respiratory improvement within 4 hours after starting therapy. The only side effect was transient hypersecretion which occurred either late into the course of therapy or after therapy was discontinued.