NOVEL ADHESIVE CARIOSTATIC CEMENTS

这项研究的目标是开发一种盖髓材料。 也可以用作基层/衬里水泥，由四元和四元组成 磷酸氢钙(TTCP和DCPA)、羟基磷灰石(HAP)和 羧化单体/聚合物。这种水泥结合了以下优点 光固化、盖髓和玻璃离子粘固剂。水泥是 被称为“合成牙本质”(SD)，因为它是由钙组成的 磷酸盐和一种聚合物。 该提案的具体目的是：(1)用以下物质配制水泥 足够的pH值水平8-10和10-12和径向抗拉强度 (2)将SD与物理试剂制成双糊剂体系 储存6个月内跌幅不超过20%的物业， (3)研制对牙本质具有粘附性的SD，同时保持理想的pH 并通过调整树脂、填料的组成来提高强度，(4) 引入抗龋性，(5)在体内评价SD，通过研究 牙本质桥接在裸露牙髓上的刺激作用(5) 评价牙本质替代物的器质性和/或毒性 分析。 实验设计旨在优化pH值和强度，这将 对两种树脂体系和四种浓度的三氯三氯酚进行测量 钙磷比分别为1.96和2.05。树脂系统由以下组成 均苯四甲酸甘油二甲基丙烯酸酯和两个羧基和一个 无羧基稀释剂树脂。为方便使用SD，一种双糊剂 系统将在存储1个月、3个月和6个月后进行24小时DTS测试。 影响SD与牙本质粘附性的因素有：(1)类型 树脂，(Ii)液体中水的存在，(Iii) 填料类型和(Iv)浓度，以及(V)内部 固化水泥中的应力。2/5-1部分析因设计将 用来评价因子I-V对pH、DTS和剪切力的影响 结合强度。两种精选的SD配方将在体内进行测试 在狗暴露的牙髓上(每个配方7颗牙)。的重现性 牙本质替代物的材料性能将通过 渗透性、XPS和IR光谱。

The goals of the proposed research are to develop a pulp-capping material that can also serve as a base/lining cement, consisting of tetra- and dicalcium phosphates (TTCP and DCPA), hydroxyapatite (HAp) and carboxylated monomers/polymers. The cement combines the advantages of light-curing, pulp-capping and glass ionomer cements. The cement is termed "Synthetic Dentin" (SD) because it is composed of calcium phosphates and a polymer. The specific aims of the proposal are: (1) to formulate cements with sufficient pH levels of 8-10 and 10-12 and diametral tensile strength (DTS) of 16 MPa, (2) to make a two-paste system of SD with physical properties that do not decline more than 20% within 6 months of storage, (3) to develop SD with adhesiveness to dentin while maintaining ideal pH and high strength by adjusting the composition of resin, fillers, (4) to introduce anticariogenicity, (5) to evaluate SD in vivo, by studying the stimulation of dentin bridging over exposed pulps in animal teeth, (5) to evaluate a dentin substitute for instrumental and/or toxicity analyses. The experimental design intends to optimize pH and strengths, which will be measured for two resin systems and four concentrations of TTCP with the two Ca/P ratios of 1.96 and 2.05. The resin systems consist of pyromellitic glycerol dimethacrylate and two carboxylated and one carboxyl-free diluent resin. To facilitate the use of SD, a two-paste system will be tested by 24 h DTS after 1, 3, and 6 months of storage. Factors influencing the adhesiveness of SD to dentin are: (i) the type of resin, (ii) the presence of water in the liquid phase, (iii) the filler type and (iv) concentration, and (v) the presence of internal stresses in the cured cement. A 2/5-1 fractional factorial design will be used to evaluate the effect of factors i-v on pH, DTS and the shear bond strength. Two selected formulations of SD will be tested in vivo on exposed pulps in dogs (7 teeth per formulation). Reproducibility of material properties of the dentin substitute will be assessed by permeability, XPS and IR spectroscopy.