MOLECULAR AND CELLULR TOXICOLOGY

国家环境健康科学研究所分子中心 和细胞毒理学与人类应用提出了与 协调和促进跨学科的总体目标 既定调查人员之间的互动和合作 进行高质量的研究和临床研究， 环境因素对人体健康的影响。 超过4,000种人类疾病 已被归因于遗传改变的日期，其中，约。 700已映射到特定的染色体与约。300个变种人 基因克隆和测序。 因为人类基因组的大部分 在接下来的十年里，由于许多环境因素， 直接损伤基因，或改变基因表达和/或细胞功能， 该中心的重点将是研究和临床研究， 环境因素对人类健康和疾病的影响 分子和细胞水平以及传播 毒理学对公众。 为了实现这些目标，我们 开发了一系列关于监管的四个综合研究核心， 基因表达、信号转导、生殖/发育/衰老及 人体暴露和疾病。 一系列的五个设施核心已经 开发，以协助中心的成员在他们的研究计划， 支持、促进和激励中心的专业发展。 这些支持设施，其中包括转基因动物设施， 原位杂交/免疫细胞化学设施，细胞培养设施， 一个细胞成像设备，和一个 流行病学/生物统计学/信息学/计算机支持设施， 旨在为中心成员的行为提供一般支持 并通过提供临时的 在毒理学研究和协助技术转让方面的做法。 强化课程包括但不限于系列研讨会， 年度专题研讨会、客座教授等，以及一个 将采用积极的试点项目计划，以刺激持续的 中心的成长和发展及其跨学科研究 关于影响人类健康的环境因素的方案。 一个社区 将制定和维持外联方案，其中包括 审查课程或研讨会提供给地方，州，国家和 国际参与者，以及教育计划， 中学、高中、本科和研究生水平。 高中 该计划将与NIH资助的少数民族高中合作完成 学校学生研究学徒计划，其中的成员 中心参与，并获得韦恩的补充支持 州立大学化学毒理学研究所。 介绍和 讨论当代毒理学问题（如重金属（Pb）; 溶剂等）将进行并向公众提供 通过大学运营的广播电台WDET。 该中心将收到 内部咨询委员会的指导，该委员会将提供以下方面的建议 研究方向、设施支持和浓缩计划， 外部咨询委员会将提供更全面的意见， 中心的进展，并将审查和排名提交的试点项目的建议。

A National Institute of Environmental Health Sciences Center in Molecular and Cellular Toxicology with Human Applications is proposed with the overall objective of coordinating and stimulating interdisciplinary interactions and collaborations between established investigators conducting high quality research and clinical studies on the effects of environmental factors on human health. More than 4,000 human disorders have been attributed to genetic alterations to date and, of these, approx. 700 have been mapped to specific chromosomes with approx. 300 of the mutant genes cloned and sequenced. Because most of the human genome will be sequenced in the next decade and since many environmental agents either damage genes directly, or alter gene expression and/or cell function, the focus of this Center will be on research and clinical studies which examine the influence of environmental factors on human health and disease at the molecular and cellular level and on dissemination of knowledge in toxicology to the general public. To accomplish these objectives, we have developed a series of four integrated research cores on the Regulation of Gene Expression, Signal-transduction, Reproduction/Development/Aging and Human Exposure and Disease. A series of five facility cores have been developed to assist members of the Center in their research programs and to support, enhance and stimulate the professional development of the Center. These support facilities, which include a Transgenic Animal Facility, an In Situ Hybridization/Immunocytochemistry Facility, a Cell Culture Facility, a Cell Imaging Facility, and an Epidemiology/Biostatistics/Informatics/Computer Support Facility, are intended to provide members of the Center general support in the conduct and expansion of their research progrlams by making available on temporary approaches in toxicology research and assisting in technology transfer. Enrichment programs consisting of, but not limited to, seminar series, annual thematic symposia, visiting professorships, etc., as well as an aggressive pilot project program will be employed to stimulate continued growth and development of the Center and its interdisciplinary research programs on environmental factors affecting human health. A Community Outreach Program will be developed and maintained which will consist of review courses or workshops offered to local, state, national and international participants, as well as educational programs at the middle school, high school, undergraduate and graduate levels. The high school program will be accomplished in concert with the NIH-funded Minority High School Student Research Apprenticeship Program in which members of the Center participate and which receives supplemental support from the Wayne State University Institute of Chemical Toxicology. Presentations and discussions of contemporary issues in toxicology (e.g. heavy metals (Pb); solvents, etc.) will be conducted and made available to the general public via the University-operated radio station, WDET. The center will receive guidance from an Internal Advisory Board which will provide advice on research direction, facility support, and enrichment programs and by an External Advisory Committee which will provide a more comprehensive view on Center progress and will review and rank submitted pilot project proposals.