TIMED BREEDING STUDIES IN MACAQUES

这是对其他调查人员服务的延续 提供已知孕周的妊娠并监测胎儿 恒河猴(猕猴)的生长。猴子的周期是 对照组每日注射黄体酮(5毫克/天)10次 几天。雌性与雄性在最后一次交配后的第14至21天配对 黄体酮注射。排卵和受孕发生在第16天到 18在注射黄体酮后。成功率，基于可行性 怀孕21天的胎儿，第一个周期保持在60%到70% 配对。通过每周的超声波检查来监测胎儿的发育 直到分娩的时候。在每一次检查中进行测量， 根据胎龄，确定孕囊长度， 冠臀长度、心率、股骨长度和双侧直径。 对胎盘进行评估，以确定 反常现象。这些程序使调查人员能够 在怀孕的特定阶段进行研究，并确定 对胎儿的影响。

This is a continuation of services to other investigators to provide pregnancies of known gestational ages and to monitor fetal growth in rhesus monkeys (Macaca mulatta). The monkeys' cycles are controlled by the daily injection of progesterone (5 mg/day) for 10 days. Females are paired with males on days 14 to 21 after the last progesterone injection. Ovulation and conception occurs on day 16 to 18 after the progesterone injections. Success rate, based on viable fetus at 21 days gestation, remains at 60% to 70% for first cycle matings. Fetal development is monitored by weekly ultrasound exams until time of parturition. At each exams measurements at taken, depending on gestational age, to determine gestational sac length, crown-rump length, heart rate, femur length, and bipartial diameter. Evalualtion of the placental disks are made to determine any anomalies. These procedures provide investigators with the ability to conduct studies at specific stages of gestation and to determine any effects on the fetuses.