CORE--EPIDEMIOLOGY AND BIOSTATISTICS

这项建议是为了继续进行拉什ADCC流行病学和 生物统计核心最近(1995年7月)通过 竞争性补充。核心的目标是促进使用 解决阿尔茨海默氏症研究问题的流行病学数据 疾病。核心的基础是由现有的七个数据形成的 流行病学项目。其中三个是目前的ADCC核心：(A) 临床核心，(B)宗教教团研究核心和(C) 神经病理学核心。其中四项是独立资助的相关研究 与ADCC合作：(D)芝加哥健康和老龄化项目，一个混血儿 对某地区8,300名居民的人口研究 目前正处于收集基线数据阶段的芝加哥；(E) 阿尔茨海默病进展及后果的纵向研究 411例社区阿尔茨海默病患者患病情况调查 它正在进入第三个数据收集周期，并进行后续比率 超过95%；(F)对攻击性的详细纵向研究 使阿尔茨海默病病程复杂化的行为 每周收集272人的连续数据 随访率超过90%；和(G)东波士顿研究 阿尔茨海默病，一组完整的数据集，包括研究 阿尔茨海默病的流行和发病情况，以及 地理上确定的社区的3800名居民患病情况 波士顿的。 这七个基地项目中有六个是从一开始就设计的 在实质性问题上尽可能相互补充 中的数据方面，包括标准和程序 阿尔茨海默病的诊断，认知功能的测量和 评估运动障碍、行为和抑郁症状。这个 第七，东波士顿研究是几年前设计的 但是有许多共享的方法和数据元素。核心将会 对这七个项目的数据进行综合管理。为 为了达到这个目的，这些项目被分成三组，根据 参与者与组成的最大组共享的程度 三项ADCC核心和两项招募参与者的研究 穿过这些核心。使用BLAISE直接在计算机上输入数据 系统将支持三个ADCC核心和一个关系数据 七个项目的基地将使用统一程序完成 用于所有数据集。此外，核心将增加 通过向来自拉什和其他国家的调查人员提供这些数据 合作机构获得技能的机会 以量身定制的方式高效使用数据所必需的 个人调查员的需求。

This proposal is for the continuation of a Rush ADCC Epidemiology and Biostatistics Core that was recently funded (in July, 1995) through a competitive supplement. The goal of the Core is to facilitate use of epidemiological data to address research questions concerning Alzheimer's disease. The base of the core is formed by data from seven existing epidemiological projects. Three of these are current ADCC cores: (a) the Clinical Core, (b)the Religious Orders Study Core and (c) the Neuropathology Core. Four are independently funded studies associated with the ADCC: (d) the Chicago Health and Aging Project, a biracial population study of 8,300 residents of a geographically defined area of Chicago that is currently at the stage of collecting baseline data; (e) a longitudinal study of the progression and consequences of Alzheimer's disease among 411 community-dwelling persons with Alzheimer's disease that is entering its third cycle of data collection with follow-up rates in excess of 95%; (f) a detailed longitudinal study of aggressive behavior complicating the course of Alzheimer's disease that has collected sequential data at weekly intervals for 272 persons with follow-up rates in excess of 90%; and (g)the East Boston studies of Alzheimer's disease, a group of completed data sets comprising studies of prevalent and incident Alzheimer's disease and of the course of the disease among 3,800 residents of a geographically defined neighborhood of Boston. Six of these seven base projects have been designed from the beginning to be as complementary as possible with respect to the substantive aspects of the data in each, including criteria and procedures for the diagnosis of Alzheimer's disease, measurement of cognitive function and assessment of movement disorders, behavior and depressive symptoms. The seventh, the East Boston studies, were designed several years previously but have a number of shared approaches and data elements. The core will provide integrated management of the data from these seven projects. For this purpose the projects are divided into three groups according to the degree to which participants are shared with the largest group composed of the three ADCC cores and the two studies recruiting participants through these cores. Direct computer entry of data using the Blaise system will be supported for the three ADCC cores, and a relational data base for the seven projects will be completed using uniform procedures for all data sets. In addition, the Core will increase the usefulness of these data by offering investigators from Rush and from other collaborating institutions the opportunity to acquire the skills necessary for efficient use of the data in a manner that is tailored to the needs of the individual investigator.