CORE--ANIMAL

内森休克衰老中心的核心是一个计划， 发展、维持和分发营养控制和 病理定义的啮齿动物模型，这些模型在遗传、营养或 以允许调查人员测试 关于衰老或与年龄有关的疾病的假说。 这些模型将 然后由中心研究人员在分子、细胞和 器官水平来确定衰老是否以及如何改变。 的 动物核心是这项工作的一个组成部分，其总体目标是 维护、监测和分发新的和已建立的动物模型， 检验关于潜在机制的假设的目的 衰老 动物核心的具体目标如下： 1. 建立、维护和表征几种新的啮齿动物模型 可用于研究衰老和/或与年龄相关的机制， 疾病过程。 转基因动物的聚居地 或用营养和/或药物干预治疗的患者将被 在屏障条件下维持，这些殖民地的生存 将被确定。 这些殖民地的动物将被提供给 中心调查员。 2. 为了将C57 B1/6小鼠和Fischer 344大鼠的集落维持在良好的温度下， 定义，屏障条件，并确定这些生存 殖民地 这些动物群的动物将提供给中心 调查员 3. 协调和优化动物组织的分布， 动物核心在UTHSC-SA和ALMMVH教师。 4. 协助教师维持老化的啮齿动物群体， 由独立赠款资助。 5. 为对衰老感兴趣的教师和学生提供特别建议， 畜牧业在老龄化研究中的要求。

Central to this proposal for a Nathan Shock Aging Center is a program to develop, maintain, and distribute nutritionally-controlled and pathologically-defined rodent models that are genetically, nutritionally or pharmacologically modified in ways that will allow investigators to test hypotheses concerning aging or age-related diseases. These models will then be examined by Center investigators at the molecular, cellular, and organismic levels to determine whether and how aging is altered. The Animal Core is an integral part of this effort and its overall goal is to maintain, monitor, and distribute new and established animal models for the purpose of testing hypotheses concerning the mechanism(s) underlying aging. The specific aims of the Animal Core are as follows: 1. To establish, maintain, and characterize several new rodent models that can be used to study the mechanisms of aging and/or age-related disease process. Colonies of animals that have been genetically modified or treated with a nutritional and/or pharmacological intervention will be maintained under barrier conditions, and the survival of these colonies will be determined. Animals from these colonies will be made available to Center investigators. 2. To maintain colonies of C57B1/6 mice and Fischer 344 rats under well- defined, barrier conditions and to determine the survival of these colonies. Animals from these colonies will be made available to Center investigator. 3. To coordinate and optimize the distribution of tissues from animals in the Animal Core to faculty at UTHSC-SA and ALMMVH. 4. To assist faculty in maintaining aging colonies of rodents that are supported with funds from independent grants. 5. To advise faculty and students interested in aging on the special requirements of animal husbandry in aging research.