RECOMBINANT INSULIN LIKE GROWTH FACTOR I (IGF-1) IN NORMAL AND ACROMEGALICS

垂体分泌生长激素（GH）的控制分泌是 由一个复杂的反馈系统介导， 释放激素（GHRH）和生长抑素（SRIF）分泌 下丘脑，垂体前叶和局部释放的GH 产生和/或循环胰岛素样生长因子I（IGF-I）。 的 本次调查的主要目的是确定（a）是否以及如何系统地 IGF-I调节正常男性和女性的GH分泌。 另外我们 将（B）确定IGF-I在GH中是否具有类似的调节作用 分泌的肢端肥大症，我们将（c）调查如何模式， 女性在月经周期中生长激素分泌的变化。

The control of pituitary secretion of growth hormone (GH) secretion is mediated by a complicated feedback system involving growth hormone- releasing hormone (GHRH) and somatostatin (SRIF) secretion from the hypothalamus, GH released from the anterior pituitary and locally produced and/or cirulating insulin-like growth factor I (IGF-I). The major aim of this investigation is to determine (a) if and how systemic IGF-I regulates GH secretion in normal men and women. In addition, we will (b) determine if IGF-I has a similar regulatory role in GH secretion in acromegaly and we will (c) investigate how the pattern of GH secretion changes in women during the menstrual cycle.