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INSULIN RESISTANCE, POLYCYSTIC OVARIAN DISEASE AND ACANTHOSIS NIGRICANS

INSULIN RESISTANCE, POLYCYSTIC OVARIAN DISEASE AND ACANTHOSIS NIGRICANS
胰岛素抵抗、多囊卵巢疾病和黑棘皮症
批准号:
6246288
负责人:
CHARLES A STUART
金额:
$2.71万
依托单位国家:
美国
项目类别:
财政年份:
1997
资助国家:
美国
项目状态:
已结题
起止时间:
1997-01-06 至 1997-11-30

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中文摘要
翻译
黑色素沉着症是一种常见的皮肤病变, 内源性高胰岛素血症。 我们假设患有这种疾病的患者 皮肤病变在胰岛素作用方面具有多种遗传缺陷, 其中与相似的表型和高风险相关, 非胰岛素依赖型糖尿病。 受试者将接受胰岛素治疗 每年评估反应情况,并选择受严重影响的 受试者及其父母将接受胰岛素受体评价 点突变基因。
英文摘要
Acanthosis nigricans is a commonly occurring skin lesion which indicates endogenous hyperinsulinemia. We hypothesize that patients with this skin lesion have a variety of hereditary defects in insulin action, all of which are associated with a similar phenotype and a high risk for noninsulin dependent diabetes mellitus. Subjects will have insulin responsiveness evaluated annually, and selected severely affected subjects and their parents will have evaluation of the insulin receptor gene for point mutations.
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Mechanisms by which strength training ameliorates the Metabolic Syndrome
  • 批准号:
    8006750
  • 项目类别:
  • 资助金额:
    $0.67万
  • 财政年份:
    2010
  • 负责人:
    CHARLES A STUART
  • 依托单位:
Mechanisms by which strength training ameliorates the Metabolic Syndrome
  • 批准号:
    7522195
  • 项目类别:
  • 资助金额:
    $21.3万
  • 财政年份:
    2008
  • 负责人:
    CHARLES A STUART
  • 依托单位:
Mechanisms by which exercise training ameliorates the metabolic syndrome
  • 批准号:
    8035605
  • 项目类别:
  • 资助金额:
    $38.72万
  • 财政年份:
    2008
  • 负责人:
    CHARLES A STUART
  • 依托单位:
INSULIN RESISTANCE, POLYCYSTIC OVARIAN DISEASE AND ACANTHOSIS NIGRICANS
海外基金