Discovery and mechanisms of host cell factors in HIV uncoating

HIV进入宿主细胞需要释放其衣壳，这是一种保护病毒基因组的蛋白质外壳。当细胞进化出可以阻止病毒感染的传感器时，衣壳劫持宿主蛋白质，使自己免受细胞防御。这项提议旨在发现参与宿主和病毒之间军备竞赛的蛋白质，并破译它们如何控制衣壳分解。这一发现将有助于设计抗艾滋病毒感染的新药，以及为基因治疗提供基因的新方法。

HIV entry into the host cell involves release of its capsid, a protein shell protecting the viral genome. The capsid hijacks host proteins to cloak itself from cellular defenses while the cell has evolved sensors that can block viral infection. This proposal aims to discover proteins involved in this arms race between host and virus and decipher how they control capsid disassembly. This insight will help design new drugs against HIV infection and new ways to deliver genes for gene therapies.