EFFECT OF DIETARY FAT ON COLONICAL EPITHELIAL CELLS

在流行病学和动物实验研究中，膳食脂肪与结直肠癌的发病机制有关。脂肪的摄入量和类型都是这一过程中的重要因素。关于脂肪对结肠粘膜的影响，已经提出了许多可能的机制，但都没有得到证实。这项研究将确定短期摄入高比例几种不同脂肪的饮食对具有不同结直肠癌危险因素的志愿者结肠上皮细胞周转率(细胞复制和细胞死亡之和)的影响。此外，还将探讨膳食脂肪摄入量与结肠粘膜产生各种前列腺素之间的关系。

Dietary fat has been associated with the pathogenesis of colorectal cancer in both epidemiologic and animal experimental studies. Both the amount and the type of fat consumed are important factors in this process. Many potential mechanisms for the effect of fat on the colonic mucosa have been proposed, but none have been proven. This study will determine the effect of short-term administration of a diet with a high proportion of several different fats on the turnover (the sum of cell duplication and cell death) of the colonic epithelial cells in human volunteers with different risk factors for colorectal cancer. In addition, the relationship between dietary fat intake and colonic mucosal production of various prostaglandins will be explored.