CORE--MECHANICAL TESTING

特殊外科医院的机械测试工作 调整工作重点，拓展合作关系， 响应新用户群的需求。HSS调查人员已经 首创骨力学测试，并进行了许多基本的 从纯机械的角度表征骨材料特性 透视。分子生物学和遗传学的进步现在允许 确定可能影响骨骼的局部和全身因素 诚信，让重点可以变得更加融合 “生物”和“工程”实验。因此，我们的目标是 机械检测的核心是组织和提升检测设施 在HSS提供材料和方法的测试设备和方法 骨的结构特征，通过培训研究人员在 材料和结构试验的使用和解释，以及 开发新的应用程序和方法以适应研究 核心中心生物医学研究中的研究人员计划 基地。与生物方法相适应的新的检测方法是 在核心其他地方描述的当前和计划中的实验中使用 中心的建议正在制定中，特别是在活体小的 动物实验。这些努力是作为一种“小动物”的一部分开始的 测试“用户组，由生物工程师、临床医生、 生物学家、化学家和他们的学生，一直活跃在 过去一年(核心中心的起点是哪一年 提案)。组织和重新聚焦机械设备所需的更改 测试工作可以在现有的基础设施中进行，使用 在HSS开发的成熟技术。

The mechanical testing effort at the Hospital for Special Surgery needs to adapt its focus, reach out and expand collaborative relations, and respond to the needs of a new user base. HSS investigators have pioneered bone mechanical testing and performed many fundamental characterizing bone material properties from a purely mechanical perspective. Advances in molecular biology and genetics now allow identification of local and systemic factors that can affect skeletal integrity, so that the emphasis can become more integrated between "biological" and "engineering" experiments. Therefore, the goal of the Mechanical Testing Core is to organize and enhance the testing facility at HSS by providing testing equipment and methodologies for material and structural characterization of bone, by training investigators in the use and interpretation of material and structural testing, and by developing new applications and methodologies to fit the research programs of investigators within the Core Center's biomedical research base. New testing approaches suitable to the biological approaches being used in current and planned experiments described elsewhere in the Core Center proposals are being developed, particularly for in vivo small animal experiments. These efforts were begun as part of a "small animal testing" user groups, consisting of bioengineers, clinicians, biologists, chemists, and their students, that has been active for the past year (and which was the initiation point for the Core Center proposal). The changes required to organize and refocus the mechanical testing effort can be made within the existing infrastructure, using well-established techniques developed at HSS.