CORE--ANIMAL

这项关于内森休克老龄中心的提案的核心是一个计划，以 开发、维护和分配营养受控和 病理学定义的啮齿动物模型，从遗传、营养或 药物改良的方式将使研究人员能够测试 关于衰老或年龄相关疾病的假说。这些型号将 然后由中心的研究人员在分子，细胞和 决定衰老是否以及如何改变的组织水平。这个 动物核心是这一努力的组成部分，其总体目标是 维护、监控和分发新的和已建立的动物模型 检验机制假说的目的(S) 衰老。动物核心的具体目标如下： 1.建立、维护和鉴定几种新的啮齿动物模型 可以用来研究衰老和/或与年龄相关的机制 疾病过程。经过基因改造的动物群体 或通过营养和/或药物干预进行治疗 在屏障条件下维持，以及这些殖民地的生存 将会被确定。这些殖民地的动物将被提供给 中心调查人员。 2.维持C57B1/6小鼠和Fischer 344大鼠在良好环境下的集落 明确的障碍条件，并确定这些 殖民地。来自这些殖民地的动物将被提供给中心 调查员。 3.协调和优化中国动物组织的分布 动物核心给UTHSC-SA和ALMMVH的教员。 4.协助教职员维持老化的啮齿动物聚居地 由独立赠款提供资金支持。 5.向对老龄化感兴趣的教职员工和学生提供关于 老龄化研究对畜牧业的要求。

Central to this proposal for a Nathan Shock Aging Center is a program to develop, maintain, and distribute nutritionally-controlled and pathologically-defined rodent models that are genetically, nutritionally or pharmacologically modified in ways that will allow investigators to test hypotheses concerning aging or age-related diseases. These models will then be examined by Center investigators at the molecular, cellular, and organismic levels to determine whether and how aging is altered. The Animal Core is an integral part of this effort and its overall goal is to maintain, monitor, and distribute new and established animal models for the purpose of testing hypotheses concerning the mechanism(s) underlying aging. The specific aims of the Animal Core are as follows: 1. To establish, maintain, and characterize several new rodent models that can be used to study the mechanisms of aging and/or age-related disease process. Colonies of animals that have been genetically modified or treated with a nutritional and/or pharmacological intervention will be maintained under barrier conditions, and the survival of these colonies will be determined. Animals from these colonies will be made available to Center investigators. 2. To maintain colonies of C57B1/6 mice and Fischer 344 rats under well- defined, barrier conditions and to determine the survival of these colonies. Animals from these colonies will be made available to Center investigator. 3. To coordinate and optimize the distribution of tissues from animals in the Animal Core to faculty at UTHSC-SA and ALMMVH. 4. To assist faculty in maintaining aging colonies of rodents that are supported with funds from independent grants. 5. To advise faculty and students interested in aging on the special requirements of animal husbandry in aging research.