CELL FREE ASSAY FOR INFLAMMATORY TRANSCRIPTION FACTORS

炎症反应的天然和生理抑制物是一种 非常有趣的话题。许多具有这种活性的化合物和蛋白质 已经通过基于细胞或整个动物系统进行了鉴定 已被证明可以阻断炎症效应基因的激活。这个 这项建议的目的是利用细胞自由转录试验来 直接研究炎症调节分子对血管内皮细胞的影响 转录激活过程。

Natural and physiologic inhibitors of the inflammatory response are a topic of great interest. Many compounds and proteins with such activity have been identified through cell based or whole animal systems and have been shown to block activation of inflammatory effector genes. The aim of this proposal is to utilize a cell free transcription assay to directly study the effects of inflamomodulatory molecules on the transcriptional activation process.