COCAINE EFFECTS ON CEREBRAL BLOOD FLOW--OXYGEN 15 PET

可卡因是一种常被滥用的欣快剂，具有强烈的强化作用。 动物数据表明，增强性能与 可卡因对多巴胺系统的影响 我们设计了一个正电子 发射断层扫描研究调查可卡因在人类中的活动 对多巴胺能神经支配的局部脑血流的影响及比较 地区 四名受试者注射015水30至180秒 可卡因注射后。 所有受试者报告主观欣快感 对视觉模拟量表的影响。 全脑血流量减少 所有受试者中为32 ± 8%。 最大的下降出现在60秒后 可卡因注射 我们证明了， 典型的“街头剂量”严重减少了全球血液流动。 进一步 一旦有足够的受试者数量，分析将产生数据 当地的变化。

Cocaine is a commonly abused euphoriant with strong reinforcing effects. Animal data have shown that the reinforcing properties are related to cocaine's activity on the dopamine system. We designed a Positron Emission Tomography study to investigate cocaine's activity in humans on regional cerebral flow in dopaminergically innervated and comparison regions. Four subjects were injected with 015water 30 to 180 seconds after cocaine injection. All subjects reported subjective euphoriant effects on Visual Analog Scales. Global cerebral blood flow was reduced 32+8% in all subjects. Maximal decreases were seen 60 seconds after cocaine injection. We demonstrated that doses of cocaine similar to typical "street doses" reduce global blood flow acutely. Further analyses, once adequate subject numbers are available, will yield data on local changes.