COCAINE EFFECTS ON CEREBRAL BLOOD FLOW--OXYGEN 15 PET

可卡因是一种经常被滥用的快乐剂，具有很强的增强作用。 动物数据表明，增强性能与 可卡因对多巴胺系统的影响。我们设计了一台正电子 人体内可卡因活性的发射断层扫描研究 多巴胺神经支配下局部脑血流的研究及比较 地区。四名受试者被注射了30到180秒的O15水 在注射可卡因后。所有受试者都报告主观欣快感 对视觉模拟标度的影响。全球脑血流量减少 32(在所有科目中占8%。最大降幅出现在60秒后 可卡因注射。我们证明了可卡因的剂量与 典型的“街头剂量”会严重减少全球的血流量。进一步 一旦有足够的受试者数量，分析就会产生数据 关于当地的变化。

Cocaine is a commonly abused euphoriant with strong reinforcing effects. Animal data have shown that the reinforcing properties are related to cocaine's activity on the dopamine system. We designed a Positron Emission Tomography study to investigate cocaine's activity in humans on regional cerebral flow in dopaminergically innervated and comparison regions. Four subjects were injected with O15 water 30 to 180 seconds after cocaine injection. All subjects reported subjective euphoriant effects on Visual Analog Scales. Global cerebral blood flow was reduced 32(8% in all subjects. Maximal decreases were seen 60 seconds after cocaine injection. We demonstrated that doses of cocaine similar to typical "street doses" reduce global blood flow acutely. Further analyses, once adequate subject numbers are available, will yield data on local changes.